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Primeur weekly 2016-11-21

Exascale supercomputing

Brookhaven Lab to lead and partner on DOE exascale computing projects ...

Quantum computing

World's fastest quantum simulator operating at the atomic level ...

Tracking the flow of quantum information ...

Tyndall technology lights the way for quantum computing ...

New attacks on location-based quantum cryptography ...

Focus on Europe

Fall 2016 edition of the e-IRG newsletter available ...

Fujitsu in joint intercontinental data centre coordination field trial using cold data storage ...

Asetek announces first installation using InRackCDU technology ...

Middleware

Altair PBS Cloud is Altair's latest technology to further HPC appliance solutions ...

Intel HPC Orchestrator to include PBS Pro for workload management ...

Altair expands the availability of PBS Professional ...

Adaptive Computing launches new Reporting & Analytics solution ...

Adaptive Computing opens up platform of products ...

Adaptive Computing improves ease-of-use & cost efficiency in Moab HPC Suite 9.1 release ...

Hardware

PGI accelerator compilers for POWER architecture enable easy on-ramp to GPU acceleration with POWER8 and NIVIDA NVLink ...

Liquid silicon: Computer chips could bridge the gap between computation and storage ...

Cray expands customer base for Cray Urika-GX system and previews upcoming software release ...

Fujitsu develops analysis technology to improve communication performance of virtual networks ...

Applications

NVIDIA teams with National Cancer Institute, U.S. Department of Energy to create AI platform for accelerating cancer research ...

Supercomputer simulations help develop new approach to fight antibiotic resistance ...

Earlham Institute receives supercomputing award for wheat research ...

Chinese research team that employs high performance computing to understand weather patterns wins 2016 ACM Gordon Bell Prize ...

Cray systems power deep learning in supercomputing at scale ...

IBM and Topcoder bring Watson to more than one million developers ...

IBM Watson Health and Broad Institute launch major research initiative to study why cancers become drug resistant ...

Julia for Astronomy: Parallel computing with Julia on NERSC supercomputer increases speed of image analysis 225x ...

Julia Computing and IBM present Julia for Deep Learning at SC16 ...

TOP500

Jefferson Lab's newest cluster makes TOP500 list of fastest supercomputers ...

Hewlett Packard Enterprise/SGI Cheyenne and Pleiades systems named on TOP500 list ...

The Cloud

Fujitsu and SUSE expand strategic alliance to develop and support open source products ...

IBM closes acquisition of Sanovi Technologies ...

Tencent Cloud joins IBM and Mellanox to break data sorting world records ...

IBM Watson Health and Broad Institute launch major research initiative to study why cancers become drug resistant


IBM Watson Health and the Broad Institute bring the data prowess of Watson to study cancer drug resistance in a $50M research collaboration. The goal is to identify patterns that could reveal clues into one of the greatest medical mysteries of cancer. Ultimately, scientists hope to use knowledge about how cancers become resistant to create combination therapies that prevent resistance from occurring. Courtesy of the Broad Institute.
10 Nov 2016 Cambridge - IBM Watson Health and the Broad Institute of MIT and Harvard have launched a research initiative aimed at discovering the basis of cancer drug resistance. The five year, $50 million project will study thousands of drug resistant tumours and draw on Watson's computational and machine learning methods to help researchers understand how cancers become resistant to therapies. The anonymized data will be made available to the scientific community to catalyze research worldwide.

While a growing number of cancer treatments can hold cancers in check for months or years, most cancers eventually recur. This is in part because they acquire mutations that make them drug resistant. The development of drug resistance is a major cause of nearly 600,000 annual cancer deaths in the United States alone. In a limited number of cases, scientists have discovered the cause of drug resistance, allowing the development of new drugs to overcome resistance. In most cases, however, the causes of drug resistance are not fully understood.

To help understand how cancers become resistant to specific therapies, Broad Institute will generate tumour genome sequence data from patients who initially respond to treatment but who then become drug-resistant. Broad will use new genome-editing methods to conduct large-scale cancer drug resistance studies in the laboratory, to help identify tumours' specific vulnerabilities. IBM scientists will use Watson to analyze this data and identify genomic patterns that may help researchers and clinicians predict drug sensitivity and resistance.

This new partnership is expected to help lay a new foundation for understanding the basis of drug resistance in cancer - especially the genetic mechanisms observed in patients - and accelerate research across the cancer community to turn knowledge of resistance mechanisms into therapies.

"Defeating cancer involves playing a high-stakes game of biological chess. When we make a move with a therapy, cancer often responds with a counter-move by finding a way to become resistant. The key will be learning from clinical experience, so that we know cancer's moves in advance and can plan strategies to cut off its escape routes", stated Eric Lander, founding director of the Broad Institute. "Knowing how cancers can become resistant will ultimately require learning from hundreds of thousands of patients' experiences. We're proud to work with IBM to make an important start toward this goal, and to make the information broadly available to the scientific community."

"The Broad Institute is leading the industry in areas of cancer biology, genomics and computational biology, and we are proud to bring Watson's data prowess to help researchers learn more about one of most important medical challenges that too often stands in the way of effective cancer treatment", stated John Kelly III, senior vice president, Cognitive Solutions and IBM Research. "Watson is already being used in the clinic to aid clinicians in cancer care. Our hope is that this effort, if successful, could eventually lead to significant breakthroughs. Someday, patients who would not otherwise have options in their battle against cancer may have reason for hope."

"Currently, cancer researchers have access to genomic information from only a few hundred drug-resistant cancers samples. In addition to the goals of this specific study, IBM and Broad are committed to advancing cancer research by sharing the data from thousands of tumour samples with the scientific community to accelerate progress everywhere against cancer", stated Todd Golub, M.D., chief scientific officer and founder of the cancer program at the Broad Institute. "What we and many others will learn with this information will have important implications for the future of cancer precision medicine and cancer diagnostics."

Earlier this month, IBM and Quest Diagnostics launched IBM Watson Genomics from Quest Diagnostics, a service available to oncologists nationwide to help advance precision medicine by combining cognitive computing with genomic tumour sequencing. The collaboration with the Broad Institute is the latest application of Watson for Genomics to help researchers and clinicians tackle the challenges and opportunities of cancer genomics.
Source: IBM

Back to Table of contents

Primeur weekly 2016-11-21

Exascale supercomputing

Brookhaven Lab to lead and partner on DOE exascale computing projects ...

Quantum computing

World's fastest quantum simulator operating at the atomic level ...

Tracking the flow of quantum information ...

Tyndall technology lights the way for quantum computing ...

New attacks on location-based quantum cryptography ...

Focus on Europe

Fall 2016 edition of the e-IRG newsletter available ...

Fujitsu in joint intercontinental data centre coordination field trial using cold data storage ...

Asetek announces first installation using InRackCDU technology ...

Middleware

Altair PBS Cloud is Altair's latest technology to further HPC appliance solutions ...

Intel HPC Orchestrator to include PBS Pro for workload management ...

Altair expands the availability of PBS Professional ...

Adaptive Computing launches new Reporting & Analytics solution ...

Adaptive Computing opens up platform of products ...

Adaptive Computing improves ease-of-use & cost efficiency in Moab HPC Suite 9.1 release ...

Hardware

PGI accelerator compilers for POWER architecture enable easy on-ramp to GPU acceleration with POWER8 and NIVIDA NVLink ...

Liquid silicon: Computer chips could bridge the gap between computation and storage ...

Cray expands customer base for Cray Urika-GX system and previews upcoming software release ...

Fujitsu develops analysis technology to improve communication performance of virtual networks ...

Applications

NVIDIA teams with National Cancer Institute, U.S. Department of Energy to create AI platform for accelerating cancer research ...

Supercomputer simulations help develop new approach to fight antibiotic resistance ...

Earlham Institute receives supercomputing award for wheat research ...

Chinese research team that employs high performance computing to understand weather patterns wins 2016 ACM Gordon Bell Prize ...

Cray systems power deep learning in supercomputing at scale ...

IBM and Topcoder bring Watson to more than one million developers ...

IBM Watson Health and Broad Institute launch major research initiative to study why cancers become drug resistant ...

Julia for Astronomy: Parallel computing with Julia on NERSC supercomputer increases speed of image analysis 225x ...

Julia Computing and IBM present Julia for Deep Learning at SC16 ...

TOP500

Jefferson Lab's newest cluster makes TOP500 list of fastest supercomputers ...

Hewlett Packard Enterprise/SGI Cheyenne and Pleiades systems named on TOP500 list ...

The Cloud

Fujitsu and SUSE expand strategic alliance to develop and support open source products ...

IBM closes acquisition of Sanovi Technologies ...

Tencent Cloud joins IBM and Mellanox to break data sorting world records ...