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Primeur weekly 2016-11-14

Exascale supercomputing

Berkeley Lab to lead AMR co-design centre for DOE's Exascale Computing Project ...

Exascale Computing Project announces $48 million to establish Exascale co-design centres ...

US Exascale Computing Project awards $34 million for software development ...

Quantum computing

Breakthrough in the quantum transfer of information between matter and light ...

Focus on Europe

European Commission reveals its forthcoming call for energy efficient, high performance processors ...

World-leading HPC centres partner to form accelerated computing institute ...

Atos Bull to boost Dutch research at SURFsara with first Bull sequana supercomputer installed ...

Middleware

Allinea tools yield a 50% speed up for genome applications at the Earlham Institute ...

NERSC's 'Shifter' scales up to more than 9,000 Cori KNL processors ...

DDN's Big Data storage provides Aalto University ample capacity and fast access to vital research data ...

DDN unveils industry's fastest multi-level security Lustre solution ...

DDN delivers new burst buffer appliance and updates block and file appliances, completing total product line refresh ...

Atos Bull tackles storage bottlenecks for High Performance Computing ...

Cycle Computing debuts the newest version of its groundbreaking CycleCloud ...

Hardware

University of Toronto selects CoolIT Systems to liquid cool signal processor for CHIME project ...

CoolIT Systems optimizes Trade and Match solution with custom closed-loop liquid cooling ...

SDSC to host high-speed, large data transfer experiment at SC16 Show ...

Cray XC40 "Theta" supercomputer accepted at Argonne National Laboratory ...

Cray launches next-generation supercomputer: the Cray XC50 ...

Cray reports third quarter 2016 financial results ...

Mellanox drives Virtual Reality to new levels with breakthrough performance ...

Mellanox announces 200Gb/s HDR InfiniBand solutions enabling record levels of performance and scalability ...

Computers made of genetic material? ...

CoolIT Systems to showcase best-in-class HPC liquid cooling offering at SC16 ...

Applications

BoschDoc, AHCODA-DB and OpenML winners of the Data Prize 2016 ...

Blue Waters simulates largest membrane channel made of DNA origami ...

Cray joins iEnergy, the oil and gas industry's foremost community for exploration and production ...

Large-scale computer simulations reveal biological growth processes ...

NASA science and technology advancements demonstrated at Supercomputing Conference ...

Unlocking big genetic datasets ...

Accelerating cancer research with deep learning ...

System opens up high-performance programming to non-experts ...

Studying structure to understand function within 'material families' ...

Chury is much younger than previously thought ...

TOP500

Global supercomputing capacity creeps up as Petascale systems blanket Top 100 ...

InfiniBand chosen by nearly 4x more end-users versus proprietary offerings in 2016 as shown on the TOP500 supercomputers list ...

The Cloud

SURFnet selects eight Cloud providers for Dutch education and research ...

Large-scale computer simulations reveal biological growth processes

9 Nov 2016 Amsterdam - Researchers at CWI and AMC used large-scale computer simulations to discover how cell types work together to form new blood vessels. Understanding vascular growth is essential for understanding and manipulating processes such as tumour growth, wound healing, and a number of eye diseases. The results of the simulations were published in the online journalPLOS ONE.

Computational modelling and simulations are increasingly important in the life sciences. Simulations allow for the development and testing of hypotheses in much more complex situations than lab experiments. They can be repeated many times with varying properties to generate large amounts of data in which new discoveries can be made and various hypotheses can be tested.

Researchers of CWI and AMC used computing clusters to conduct a large number of virtual experiments on blood vessel growth. Vascular growth involves two types of cells: tip cells that lead the growing sprout and stalk cells that follow behind. Experimental biologists could not agree on the mechanism by which stalk cells chase the tip cells.

The researchers in this project modelled the growth of a vascular network and performed virtual experiments using this model. By systematically varying the properties of the involved cell types, they discovered which properties are responsible for the observed task division between tip cells and stalk cells. Tip cells are less attracted to other cells than stalk cells, and tend to move away. The stalk cells however are attracted to the tip cells and follow them, in effect pushing the tip cells even further away, causing the blood vessel to grow. The first lab experiments, in which the activity of the attractor genes in the cells were manipulated, seem to confirm this hypothesis.

Understanding how blood vessels grow is important for medical researchers who want to influence this process. Examples are slowing down blood vessel growth to starve tumours, increasing growth to speed up wound healing, or, as the medical researchers in this project, to understand how the process can derail to cause eye diseases such as diabetic retinopathy.

Source: Centrum Wiskunde & Informatica - CWI

Back to Table of contents

Primeur weekly 2016-11-14

Exascale supercomputing

Berkeley Lab to lead AMR co-design centre for DOE's Exascale Computing Project ...

Exascale Computing Project announces $48 million to establish Exascale co-design centres ...

US Exascale Computing Project awards $34 million for software development ...

Quantum computing

Breakthrough in the quantum transfer of information between matter and light ...

Focus on Europe

European Commission reveals its forthcoming call for energy efficient, high performance processors ...

World-leading HPC centres partner to form accelerated computing institute ...

Atos Bull to boost Dutch research at SURFsara with first Bull sequana supercomputer installed ...

Middleware

Allinea tools yield a 50% speed up for genome applications at the Earlham Institute ...

NERSC's 'Shifter' scales up to more than 9,000 Cori KNL processors ...

DDN's Big Data storage provides Aalto University ample capacity and fast access to vital research data ...

DDN unveils industry's fastest multi-level security Lustre solution ...

DDN delivers new burst buffer appliance and updates block and file appliances, completing total product line refresh ...

Atos Bull tackles storage bottlenecks for High Performance Computing ...

Cycle Computing debuts the newest version of its groundbreaking CycleCloud ...

Hardware

University of Toronto selects CoolIT Systems to liquid cool signal processor for CHIME project ...

CoolIT Systems optimizes Trade and Match solution with custom closed-loop liquid cooling ...

SDSC to host high-speed, large data transfer experiment at SC16 Show ...

Cray XC40 "Theta" supercomputer accepted at Argonne National Laboratory ...

Cray launches next-generation supercomputer: the Cray XC50 ...

Cray reports third quarter 2016 financial results ...

Mellanox drives Virtual Reality to new levels with breakthrough performance ...

Mellanox announces 200Gb/s HDR InfiniBand solutions enabling record levels of performance and scalability ...

Computers made of genetic material? ...

CoolIT Systems to showcase best-in-class HPC liquid cooling offering at SC16 ...

Applications

BoschDoc, AHCODA-DB and OpenML winners of the Data Prize 2016 ...

Blue Waters simulates largest membrane channel made of DNA origami ...

Cray joins iEnergy, the oil and gas industry's foremost community for exploration and production ...

Large-scale computer simulations reveal biological growth processes ...

NASA science and technology advancements demonstrated at Supercomputing Conference ...

Unlocking big genetic datasets ...

Accelerating cancer research with deep learning ...

System opens up high-performance programming to non-experts ...

Studying structure to understand function within 'material families' ...

Chury is much younger than previously thought ...

TOP500

Global supercomputing capacity creeps up as Petascale systems blanket Top 100 ...

InfiniBand chosen by nearly 4x more end-users versus proprietary offerings in 2016 as shown on the TOP500 supercomputers list ...

The Cloud

SURFnet selects eight Cloud providers for Dutch education and research ...