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Primeur weekly 2017-09-18

Special

2017 - Another year on the Road to Exascale: The state of exascale progress today ...

Focus

ETP4HPC plays instrumental role in development of European exascale programme ...

Atos/Bull to provide customers with mix of processor architectures and new BXI interconnect ...

Quantum computing

IBM pioneers new approach to simulate chemistry with quantum computing ...

The dark side of quantum computers ...

Toward unbreakable encrypted messages ...

First on-chip nanoscale optical quantum memory developed ...

Focus on Europe

HPC Advisory Council and ISC Group announce the 2018 Student Cluster Competition ...

Digital Infrastructures for Research 2017 to announce Call for Abstracts ...

HPC alliance GW4 shortlisted for Times Higher Education award ...

New GPU power for machine learning and HPC at CSC Finland ...

Mexico launches HPC initiative for Energy Research and Development supported by BSC ...

Middleware

PGI 17.7 compilers for heterogeneous supercomputing now available ...

Hardware

Supermicro launches petabyte scale 1U server and JBOF ...

Packet partners with Arm to accelerate adoption of Armv8-A for data centre workloads ...

Xilinx, Arm, Cadence, and TSMC announce world's first CCIX silicon demonstration vehicle in 7nm process technology ...

Applications

Supercomputing power to study brain function ...

Julia joins Petaflop Club ...

BSC participates in eTRANSAFE, a project for new drug safety assessment and integrative data analysis research ...

NERSC supercomputers help Berkeley Lab scientists map key DNA protein complex ...

Study clarifies how neural nets think when processing language ...

Modelling a city's minuscule changes ...

The Cloud

Oracle joins the Cloud Native Computing Foundation ...

Dell EMC and IBM to offer VMware solutions on the IBM Cloud ...

VMware speeds customer time to value for SDDC and multi-Cloud management with new vRealize suite 2017 ...

BSC participates in eTRANSAFE, a project for new drug safety assessment and integrative data analysis research


13 Sep 2017 Barcelona - Barcelona Supercomputing Center (BSC) participates in eTRANSAFE through ELIXIR, which is one of the 26 international partners in this project. The five-year project, Enhancing Translational Safety Assessment through Integrative Knowledge Management (eTRANSAFE), aims to develop an advanced data integration infrastructure together with innovative computational methods to improve the security in drug development process. The eTRANSAFE project aims at improving the safety assessment across the drug discovery and development process by applying bioinformatics approaches to shared preclinical and clinical data to systematically analyse the translatability of effects. Thus, enabling the optimisation of resources and the development of safer medicines.

The five-year eTRANSAFE project is funded by the Innovative Medicines Initiative 2 Joint Undertaking (IMI 2) together with the pharmaceutical industry.

The eTRANSAFE consortium is a private and public partnership of 8 academic institutions, 6 SMEs and 12 pharmaceutical companies, and is coordinated by the Fundació Institut Mar d'Investigacions Mèdiques (IMIM) and led by the pharmaceutical company Novartis.

"The safety of new drug candidates in first clinical trials is extrapolated based on preclinical animal data. These extrapolations are made using solely the data generated for the project at hand, since a global and systematic analysis of predictivity of the entire collective historical data pool has never been made", stated Project leader Francois Pognan from Novartis. "It is often poorly known to what extent and frequency an observed effect in an animal species may translate into a human effect", added deputy leader Thomas Steger-Hartmann from Bayer.

Based on the experience gained in the previous eTOX project, the eTRANSAFE project will carry out key efforts in the field of data standardisation and quality control, promoting the development and implementation of relevant data sharing policies and procedures that will have a great global impact in the community. eTRANSAFE will catalyse the transformation of drug safety modelling from monolithic applications and isolated data repositories to an open innovation ecosystem based on open standards, modular components and data integration services.

Professor Ferran Sanz, coordinator of the project, stated: "eTRANSAFE will improve translational safety assessment and contribute to the key scientific policies, such as the reduce, reuse, recycle (3Rs) one and the FAIR principles for data sharing."

The main specific objectives of the eTRANSAFE project are:

  • The development of a state-of-the-art, powerful and flexible strategy and technological architecture for data sharing (diverse sources of nonclinical and clinical data), data integration and data exploitation.
  • The implementation of the following key elements for this architecture: a specialised SEND ("standards for the exchange of non-clinical data") data management system, a database of shared proprietary data managed by an honest broker, a Knowledge Hub providing seamless access to all the databases and data sources, and an ecosystem of data exploitation modules.
  • The establishment of overarching policies and guidelines for safeguarded data sharing, secondary use of human safety data and use of pooled data and models in drug safety assessment.
  • Optimising how preclinical studies are run and how the industry designs these studies.

The project is coordinated and led by Fundació Institut Mar d'Investigacions Mèdiques (Coordinator); Novartis Pharma AG (Leader); Synapse Research Management Partners SL (Co-coordinator); and Bayer AG (Deputy Leader).

The eTRANSAFE partners are:

  • Fundació Institut Mar d'Investigacions Mèdiques (IMIM)
  • Synapse Research Management Partners S.L.
  • Lhasa Limited
  • European Molecular Biology Laboratory (for ELIXIR)
  • Erasmus Universitair Medisch Centrum Rotterdam
  • Universiteit Leiden
  • Universität Wien
  • Simcyp Limited
  • Molecular Networks GmbH; Computerchemie
  • Optibrium Limited
  • Liverpool John Moores University
  • Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V.
  • PDS Computer Software Limited
  • Universitat Pompeu Fabra
  • Novartis Pharma AG
  • Bayer AG
  • Sanofi-Aventis Deutschland GmbH
  • F. Hoffmann-La Roche AG
  • Merck KGaA
  • Janssen Pharmaceutica NV
  • Institute de Recherche Internationales Servier
  • AbbVie Inc
  • AstraZeneca AB
  • Boehringer Ingelheim International Computerchemie GmbH
  • Clarivate Analytics
  • IPSEN Innovation SAS

eTRANSAFE is funded through the Innovative Medicines Initiative (IMI), Europe's largest public-private initiative aiming to speed up the development of better and safer medicines for patients. eTRANSAFE has received support from IMI2 Joint Undertaking under Grant Agreement No. 777365. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). IMI supports collaborative research projects and builds networks of industrial and academic experts in order to boost pharmaceutical innovation in Europe.

For more information you can visit the eTRANSAFE project website.

Source: Barcelona Supercomputing Center - BSC

Back to Table of contents

Primeur weekly 2017-09-18

Special

2017 - Another year on the Road to Exascale: The state of exascale progress today ...

Focus

ETP4HPC plays instrumental role in development of European exascale programme ...

Atos/Bull to provide customers with mix of processor architectures and new BXI interconnect ...

Quantum computing

IBM pioneers new approach to simulate chemistry with quantum computing ...

The dark side of quantum computers ...

Toward unbreakable encrypted messages ...

First on-chip nanoscale optical quantum memory developed ...

Focus on Europe

HPC Advisory Council and ISC Group announce the 2018 Student Cluster Competition ...

Digital Infrastructures for Research 2017 to announce Call for Abstracts ...

HPC alliance GW4 shortlisted for Times Higher Education award ...

New GPU power for machine learning and HPC at CSC Finland ...

Mexico launches HPC initiative for Energy Research and Development supported by BSC ...

Middleware

PGI 17.7 compilers for heterogeneous supercomputing now available ...

Hardware

Supermicro launches petabyte scale 1U server and JBOF ...

Packet partners with Arm to accelerate adoption of Armv8-A for data centre workloads ...

Xilinx, Arm, Cadence, and TSMC announce world's first CCIX silicon demonstration vehicle in 7nm process technology ...

Applications

Supercomputing power to study brain function ...

Julia joins Petaflop Club ...

BSC participates in eTRANSAFE, a project for new drug safety assessment and integrative data analysis research ...

NERSC supercomputers help Berkeley Lab scientists map key DNA protein complex ...

Study clarifies how neural nets think when processing language ...

Modelling a city's minuscule changes ...

The Cloud

Oracle joins the Cloud Native Computing Foundation ...

Dell EMC and IBM to offer VMware solutions on the IBM Cloud ...

VMware speeds customer time to value for SDDC and multi-Cloud management with new vRealize suite 2017 ...