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Primeur weekly 2017-09-11

Focus

In Europe applications are driving the hardware developers towards exascale ...

Airbus needs HPC capacity to stay competitive ...

PPI4HPC procurement of 4 European supercomputers - what is it all about? ...

Crowd computing

BOINC community active in new version release, project management change and welcoming new sites ...

Quantum computing

Quantum detectives in the hunt for the world's first quantum computer ...

Flip-flop qubits: Radical new quantum computing design invented ...

Microsoft establishes quantum center at the University of Copenhagen ...

High-speed quantum memory for photons ...

Focus on Europe

Asetek announces new OEM, channel partner, and HPC installation ...

Fast magnetic writing of data ...

e-IRG Workshop to address European Open Science Cloud governance ...

Middleware

Univa releases open source Universal Resource Broker for Kubernetes ...

TACC supports parallel data analysis using popular software package, adapts R for co-processors ...

Avitas Systems, a GE venture, partners with NVIDIA to enhance AI for robotic inspection and automated defect recognition ...

Letting programmes manage their own processing resources ...

Hardware

Supermicro accelerates software-defined storage with VMware vSAN hyper-converged solution ...

Launch of the Canadian Hydrogen Intensity Mapping Experiment supported by CoolIT Systems Liquid Cooling ...

Cray signs solutions provider agreement with Vanguard Infrastructures ...

Solarflare XtremeScale NICs accelerate performance of NGINX application delivery ...

Applications

Ohio Supercomputer Center releases open-source HPC access portal ...

Improving cancer surgery with real-time image processing ...

CureMatch co-founders study molecular alterations of genes to develop personalized cancer therapy options ...

IBM and MIT to pursue joint research in artificial intelligence and establish new MIT–IBM Watson AI Lab ...

AA-ALERT project detects Fast Radio Burst ...

Particle physicists on a quest for new physics ...

Artificial Intelligence and Blockchain Technology for Healthcare Forum at the Basel Life Conference ...

The Cloud

Huawei releases FusionServer G series heterogeneous computing platform ...

Army re-ups with IBM for $135 million in Cloud services ...

CureMatch co-founders study molecular alterations of genes to develop personalized cancer therapy options

30 Aug 2017 San Diego - CureMatch co-founders Igor Tsigelny, Ph.D. and Razelle Kurzrock, M.D. along with colleagues from the San Diego Supercomputer Center and UCSD Moores Cancer Center have published a study in the journalCancer Biology & Therapy, highlighting the role of a specific molecular mutation in eosinophilic cystitis, a rare inflammatory bladder condition associated with painful and bloody urination.

This study is significant because treatment of eosinophilic cystitis can be challenging, and the root cause is not known. The authors suggest that there is an association between a specific BRAF oncogene mutation and the disease. Liquid biopsy techniques, which applied genomic sequencing of circulating DNA isolated from a small vial of blood, detected a BRAF I463T mutation. It is important to note that liquid biopsies can identify these potentially important genomic alterations in patients for whom traditional biopsies may be difficult in terms of risk or cost.

The identification of this specific mutation can refine treatment in some cases. The growing field of genomics drives precision medicine for oncology patients, and researchers such as Igor Tsigelny and Razelle Kurzrock are providing breakthroughs in this field. Genetic markers of cancer provide some of the best indicators to recommend personalized treatments and improve survival rates.

As pointed out by Dr. Tsigelny, "It was a challenge to elucidate the functional effect of the I463T mutation in the BRAF protein. Only sophisticated modelling by the computer and molecular dynamics simulation established that this mutation is likely to cause abnormally high activity of the BRAF protein."

However, genetic information can only be translated into advanced treatment decisions when analyzed in conjunction with massive clinical and pharmacological knowledge databases, and CureMatch is a digital health company which does just that. CureMatch offers oncologists actionable intelligence by scoring millions of potential combinations of cancer drugs for each individual patient. Extensively analyzing cancer treatment options via proprietary algorithms and evidence-based, custom-curated databases of genomics and proteomics information, CureMatch generates reports for oncologists ranking the best Personalized Combination Therapy options for each patient.

Physicians are able to uncover potential therapeutic options that target specific genetic alterations via data-driven reports generated by CureMatch's Decision Support System. Ultimately, oncologists review CureMatch Reports to recommend patient treatment plans based on the most current targeted treatments available. By matching treatments at the molecular level, doctors are able to target the unique nature of each individual patient's tumours, and improved outcomes are the result.

"CureMatch helps oncologists make more informed decisions. Our platform was founded by prominent physicians and researchers who, for years, have been studying and applying genomic insights to personalize cancer treatment with great success", stated Stephane Richard Ph.D., CureMatch President and COO.

The study " BRAF Mutation as a Novel Driver of Eosinophilic Cystitis " was published inCancer Biology & Therapy Journalby CureMatch co-founders Igor F. Tsigelny, Ph.D. and Razelle Kurzrock. M.D., who also have faculty appointments at the UCSD Moores Cancer Center. Co-authors of the article are Michael Y Choi, Amelie Boichard, Åge A. Skjevik, and Ahmed Shabaik.
Source: CureMatch

Back to Table of contents

Primeur weekly 2017-09-11

Focus

In Europe applications are driving the hardware developers towards exascale ...

Airbus needs HPC capacity to stay competitive ...

PPI4HPC procurement of 4 European supercomputers - what is it all about? ...

Crowd computing

BOINC community active in new version release, project management change and welcoming new sites ...

Quantum computing

Quantum detectives in the hunt for the world's first quantum computer ...

Flip-flop qubits: Radical new quantum computing design invented ...

Microsoft establishes quantum center at the University of Copenhagen ...

High-speed quantum memory for photons ...

Focus on Europe

Asetek announces new OEM, channel partner, and HPC installation ...

Fast magnetic writing of data ...

e-IRG Workshop to address European Open Science Cloud governance ...

Middleware

Univa releases open source Universal Resource Broker for Kubernetes ...

TACC supports parallel data analysis using popular software package, adapts R for co-processors ...

Avitas Systems, a GE venture, partners with NVIDIA to enhance AI for robotic inspection and automated defect recognition ...

Letting programmes manage their own processing resources ...

Hardware

Supermicro accelerates software-defined storage with VMware vSAN hyper-converged solution ...

Launch of the Canadian Hydrogen Intensity Mapping Experiment supported by CoolIT Systems Liquid Cooling ...

Cray signs solutions provider agreement with Vanguard Infrastructures ...

Solarflare XtremeScale NICs accelerate performance of NGINX application delivery ...

Applications

Ohio Supercomputer Center releases open-source HPC access portal ...

Improving cancer surgery with real-time image processing ...

CureMatch co-founders study molecular alterations of genes to develop personalized cancer therapy options ...

IBM and MIT to pursue joint research in artificial intelligence and establish new MIT–IBM Watson AI Lab ...

AA-ALERT project detects Fast Radio Burst ...

Particle physicists on a quest for new physics ...

Artificial Intelligence and Blockchain Technology for Healthcare Forum at the Basel Life Conference ...

The Cloud

Huawei releases FusionServer G series heterogeneous computing platform ...

Army re-ups with IBM for $135 million in Cloud services ...