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Primeur weekly 2016-09-26

Focus

OpenPOWER and IBM at the verge of the era of cognitive computing ...

Exascale supercomputing

Supercomputers receive funding to help predict and modify new materials ...

Focus on Europe

Calling on experts to propose tutorials and workshops for ISC 2017 ...

Adept project concludes with open-source release of energy measurement tools ...

Specific Grant Agreement One signed by the European Commission and the Human Brain Project ...

University of Amsterdam coordinates cognition research in Human Brain Project ...

New EU publication on Science, research and innovation performance of the European Union ...

Middleware

Quantum names Molly Rector Vice President of Marketing ...

IBM Research and MIT collaborate to advance frontiers of artificial intelligence in real-world audio-visual comprehension technologies ...

Hardware

UC San Diego Extension and San Diego Supercomputer Center launch Modern Data Science Academy ...

TSMC and Synopsys collaboration delivers innovative technologies for the High Performance Compute (HPC) Platform ...

Cadence and TSMC advance 7nm FinFET designs for mobile and HPC platforms ...

Volkswagen innovates manufacturing with move to Verne Global ...

Kinetica unveils GPU-accelerated database for analyzing streaming data with enhanced performance, visualization and high availability ...

CORNAMI announces $3 million funding led by Impact Venture Capital ...

Mellanox Technologies appoints Alinka Flaminia as Senior Vice President and General Counsel ...

DataCore and Supermicro offer ultra-high performance enterprise class Hyper-converged solutions ...

TYAN HPC platforms add support for NVIDIA Tesla P100, P40 and P4 GPUs ...

CENATE adds powerful testbed from NVIDIA ...

Reconfigurable chaos-based microchips offer possible solution to Moore's law ...

New Hikari supercomputer starts solar HVDC ...

India's North East region's fastest supercomputer launched by honourable Union Minister for HRD at IIT Guwahati ...

DDN leverages Lustre leadership to deliver new scalability and management capabilities and open source contributions ...

Applications

Termination of lethal arrhythmia with light ...

Artificial intelligence reveals mechanism behind brain tumour ...

Tracking down the origin of mercury contamination in human hair ...

Next generation of statistical tools to be developed for the Big Data age ...

British Artificial Intelligence firm first in Europe to use advanced deep learning supercomputer ...

Denver International Airport selects Panasonic Weather Solutions for ground operations weather forecasting ...

Ansys and TSMC empower chip manufacturers to design cutting-edge multi-die chip-package systems ...

New study shows nickel graphene can be tuned for optimal fracture strength ...

Meet Rutgers' RADICAL supercomputing guru ...

NASA Career Award winner uses Blue Waters supercomputer to mine crop yield data ...

Southeast students and faculty optimize knowledge at Supercomputing Symposium ...

The Cloud

Oracle unveils its next generation Cloud strategy: Intelligent Applications ...

Oracle announces the industry's most comprehensive offering for analytics in the Cloud ...

IBM Power Systems and Red Hat extend collaboration for next-generation Cloud platforms ...

Trifacta v4 extends enterprise data wrangling to any user, any data, any Cloud ...

Salesforce introduces Salesforce Einstein - artificial intelligence for everyone ...

Artificial intelligence reveals mechanism behind brain tumour

19 Sep 2016 Uppsala - Researchers at Uppsala University have used computer modelling to study how brain tumours arise. The study, which is published in the journalEBioMedicine, illustrated how researchers in the future will be able to use large-scale data to find new disease mechanisms and identify new treatment targets.

The last ten years' progress in molecular biology has drastically changed how cancer researchers work. Instead of almost exclusively using different biological models, like cells, today large-scale statistical analyses are increasingly used to understand tumour diseases and find new therapies.

Researchers at Uppsala University, together with colleagues at the University of Gothenburg, Chalmers University of Technology and University of Freiburg, have developed a new algorithm, aSICS, that uses large amounts of data to suggest hypotheses about "what causes what" in a cancer cell.

In the study the researchers used aSICS to interpret data from brain tumours and they could identify a new mechanism behind mesenchymal glioblastoma, an extra aggressive brain tumour type.

"According to the computer model, mesenchymal glioblastoma is partly caused by alterations in a gene called Annexin A2. To validate the relevance of this prediction we examined samples from patients and could show that mesenchymal glioblastoma have an increased activity of Annexin A2. Subsequently, we tested to inhibit the expression of Annexin A2 in cancer cells from patients and found that the cancer cells either died or changed to a less aggressive form", stated Sven Nelander at the Department of Immunology, Genetics and Pathology at Uppsala University, who has led the study together with a colleague in Freiburg.

The results show that data analyses can be used to predict which genes or proteins influence the development of a tumour, and then confirm the prediction with experiments in the lab. The aSICS method has also been tested on other kinds of cancer, with promising results, although further studies are needed to fine-tune the settings.

The study titled " Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma ", authored by Nelander et al., appears in

Source: Uppsala Universitet

Back to Table of contents

Primeur weekly 2016-09-26

Focus

OpenPOWER and IBM at the verge of the era of cognitive computing ...

Exascale supercomputing

Supercomputers receive funding to help predict and modify new materials ...

Focus on Europe

Calling on experts to propose tutorials and workshops for ISC 2017 ...

Adept project concludes with open-source release of energy measurement tools ...

Specific Grant Agreement One signed by the European Commission and the Human Brain Project ...

University of Amsterdam coordinates cognition research in Human Brain Project ...

New EU publication on Science, research and innovation performance of the European Union ...

Middleware

Quantum names Molly Rector Vice President of Marketing ...

IBM Research and MIT collaborate to advance frontiers of artificial intelligence in real-world audio-visual comprehension technologies ...

Hardware

UC San Diego Extension and San Diego Supercomputer Center launch Modern Data Science Academy ...

TSMC and Synopsys collaboration delivers innovative technologies for the High Performance Compute (HPC) Platform ...

Cadence and TSMC advance 7nm FinFET designs for mobile and HPC platforms ...

Volkswagen innovates manufacturing with move to Verne Global ...

Kinetica unveils GPU-accelerated database for analyzing streaming data with enhanced performance, visualization and high availability ...

CORNAMI announces $3 million funding led by Impact Venture Capital ...

Mellanox Technologies appoints Alinka Flaminia as Senior Vice President and General Counsel ...

DataCore and Supermicro offer ultra-high performance enterprise class Hyper-converged solutions ...

TYAN HPC platforms add support for NVIDIA Tesla P100, P40 and P4 GPUs ...

CENATE adds powerful testbed from NVIDIA ...

Reconfigurable chaos-based microchips offer possible solution to Moore's law ...

New Hikari supercomputer starts solar HVDC ...

India's North East region's fastest supercomputer launched by honourable Union Minister for HRD at IIT Guwahati ...

DDN leverages Lustre leadership to deliver new scalability and management capabilities and open source contributions ...

Applications

Termination of lethal arrhythmia with light ...

Artificial intelligence reveals mechanism behind brain tumour ...

Tracking down the origin of mercury contamination in human hair ...

Next generation of statistical tools to be developed for the Big Data age ...

British Artificial Intelligence firm first in Europe to use advanced deep learning supercomputer ...

Denver International Airport selects Panasonic Weather Solutions for ground operations weather forecasting ...

Ansys and TSMC empower chip manufacturers to design cutting-edge multi-die chip-package systems ...

New study shows nickel graphene can be tuned for optimal fracture strength ...

Meet Rutgers' RADICAL supercomputing guru ...

NASA Career Award winner uses Blue Waters supercomputer to mine crop yield data ...

Southeast students and faculty optimize knowledge at Supercomputing Symposium ...

The Cloud

Oracle unveils its next generation Cloud strategy: Intelligent Applications ...

Oracle announces the industry's most comprehensive offering for analytics in the Cloud ...

IBM Power Systems and Red Hat extend collaboration for next-generation Cloud platforms ...

Trifacta v4 extends enterprise data wrangling to any user, any data, any Cloud ...

Salesforce introduces Salesforce Einstein - artificial intelligence for everyone ...