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Primeur weekly 2016-08-08

Focus

OpenSoC Fabric to create Open Source Network-on-Chip systems for demonstration purposes ...

ExaNoDe project is looking for chiplet solutions stacked on an active silicon interposer ...

Quantum computing

New quantum computer module sets stage for general-purpose quantum computers ...

Diamond-based light sources will lay a foundation for quantum communications of the future ...

Focus on Europe

IBM scientists imitate the functionality of neurons with a phase-change device ...

European Commission issues booklet on e-Infrastructures as the foundation of the European Open Science Cloud ...

Middleware

Bright Computing releases Version 7.3 of Bright Cluster Manager and Bright OpenStack ...

Hardware

HiPEAC community delivers video processing with up to eight times faster edge detection and 50 times faster motion detection ...

AMD open sources professional GPU-optimized photorealistic renderer ...

Curtiss-Wright collaborates with Dolphin Interconnect Solutions to dramatically increase HPEC system fabric speed ...

New UK consortium to explore use of magnetic skyrmions in data storage ...

Smallest photodetector worldwide for optical data transmission ...

Cray reports second quarter 2016 financial results and updates 2016 outlook ...

Panasas introduces ActiveStor 20 ...

World's Highest Density Deep Learning Supercomputer in a Box by Joint Creators Orange and CoCoLink Korea ...

Applications

Rail researchers select liquid cooled computing for Big Data risk analysis ...

SC16 selects industry veteran Katharine Frase as keynote speaker ...

University of Kentucky biology graduate student wins prestigious Blue Waters Fellowship ...

Partnership between University of Maryland and U.S. Army Research Laboratory harnesses the power of defense supercomputing to create opportunities for scientific discovery ...

Personalized virtual brains: Big data - big theory ...

Analysis of metastatic prostate cancers suggests treatment options ...

Penn researchers improve computer modeling for designing drug-delivery nanocarriers ...

The Cloud

5.3 million euro HNSciCloud tender for Hybrid Cloud Platform released ...

IBM captures leadership position in hybrid Cloud environment adoption, according to research firm ...

IBM named leader in private Cloud adoption by market research firm ...

Penn researchers improve computer modeling for designing drug-delivery nanocarriers


Previous work by some of the researchers uncovered a counter-intuitive relationship that suggested that adding more targeting molecules on the nanocarrier's surface is not always better, as increases in stability. Credit: University of Pennsylvania.
4 Aug 2016 Philadelphia - A team of University of Pennsylvania researchers has developed a computer model that will aid in the design of nanocarriers, microscopic structures used to guide drugs to their targets in the body. The model better accounts for how the surfaces of different types of cells undulate due to thermal fluctuations, informing features of the nanocarriers that will help them stick to cells long enough to deliver their payloads.

The study was led by Ravi Radhakrishnan, a professor in the departments of bioengineering and chemical and biomolecular engineering in Penn's School of Engineering and Applied Science, and Ramakrishnan Natesan, a member of his lab.

Also contributing to the study were Richard Tourdot, a Radhakrishnan lab member; David Eckmann, the Horatio C. Wood Professor of Anesthesiology and Critical Care in Penn's Perelman School of Medicine; Portonovo Ayyaswamy, the Asa Whitney Professor of Mechanical Engineering and Applied Mechanics in Penn Engineering; and Vladimir Muzykantov, a professor of pharmacology in Penn Medicine. It was published in the journalRoyal Society Open Science.

Nanocarriers can be designed with molecules on their exteriors that only bind to biomarkers found on a certain type of cell. This type of targeting could reduce side effects, such as when chemotherapy drugs destroy healthy cells instead of cancerous ones, but the biomechanics of this binding process are complex.

Previous work by some of the researchers uncovered a counter-intuitive relationship that suggested that adding more targeting molecules on the nanocarrier's surface is not always better.

A nanocarrier with more of those targeting molecules might find and bind to many of the corresponding biomarkers at once. While such a configuration is stable, it can decrease the nanocarrier's ability to distinguish between healthy and diseased tissues. Having fewer targeting molecules makes the nanocarrier more selective, as it will have a harder time binding to healthy tissue where the corresponding biomarkers are not over-expressed.

The team's new study adds new dimensions to the model of the interplay between the cellular surface and the nanocarrier.

"The cell surface itself is like a caravan tent on a windy day on a desert", Ravi Radhakrishnan stated. "The more excess in the cloth, the more the flutter of the tent. Similarly, the more excess cell membrane area on the 'tent poles', the cytoskeleton of the cell, the more the flutter of the membrane due to thermal motion."

The Penn team found that different cell types have differing amounts of this excess membrane area and that this mechanical parameter governs how well nanocarriers can bind to the cell. Accounting for the fluttering of the membrane in their computer models, in addition to the quantity of targeting molecules on the nanocarrier and biomarkers on the cell surface, has highlighted the importance of these mechanical aspects in how efficiently nanocarriers can deliver their payloads.

"These design criteria", Ravi Radhakrishnan stated, "can be utilized in custom designing nanocarriers for a given patient or patient-cohort, hence showing an important way forward for custom nanocarrier design in the era of personalized medicine."

The research was supported by the National Science Foundation through grants DMR-1120901, CBET-1236514 and MCB060006, and the National Institutes of Health through grants U01EB016027, 1R01EB006818-05, HL125462 and HL087936.

Source: University of Pennsylvania

Back to Table of contents

Primeur weekly 2016-08-08

Focus

OpenSoC Fabric to create Open Source Network-on-Chip systems for demonstration purposes ...

ExaNoDe project is looking for chiplet solutions stacked on an active silicon interposer ...

Quantum computing

New quantum computer module sets stage for general-purpose quantum computers ...

Diamond-based light sources will lay a foundation for quantum communications of the future ...

Focus on Europe

IBM scientists imitate the functionality of neurons with a phase-change device ...

European Commission issues booklet on e-Infrastructures as the foundation of the European Open Science Cloud ...

Middleware

Bright Computing releases Version 7.3 of Bright Cluster Manager and Bright OpenStack ...

Hardware

HiPEAC community delivers video processing with up to eight times faster edge detection and 50 times faster motion detection ...

AMD open sources professional GPU-optimized photorealistic renderer ...

Curtiss-Wright collaborates with Dolphin Interconnect Solutions to dramatically increase HPEC system fabric speed ...

New UK consortium to explore use of magnetic skyrmions in data storage ...

Smallest photodetector worldwide for optical data transmission ...

Cray reports second quarter 2016 financial results and updates 2016 outlook ...

Panasas introduces ActiveStor 20 ...

World's Highest Density Deep Learning Supercomputer in a Box by Joint Creators Orange and CoCoLink Korea ...

Applications

Rail researchers select liquid cooled computing for Big Data risk analysis ...

SC16 selects industry veteran Katharine Frase as keynote speaker ...

University of Kentucky biology graduate student wins prestigious Blue Waters Fellowship ...

Partnership between University of Maryland and U.S. Army Research Laboratory harnesses the power of defense supercomputing to create opportunities for scientific discovery ...

Personalized virtual brains: Big data - big theory ...

Analysis of metastatic prostate cancers suggests treatment options ...

Penn researchers improve computer modeling for designing drug-delivery nanocarriers ...

The Cloud

5.3 million euro HNSciCloud tender for Hybrid Cloud Platform released ...

IBM captures leadership position in hybrid Cloud environment adoption, according to research firm ...

IBM named leader in private Cloud adoption by market research firm ...