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Primeur weekly 2017-07-10

Focus

ELIXIR is working hard trying to find a common Key Performance Indicator vocabulary between research infrastructures ...

HPC in Asia - Status report from China ...

Quantum computing

Atos launches the highest-performing quantum simulator in the world ...

New method could enable more stable and scalable quantum computing, Penn physicists report ...

Focus on Europe

UK Atomic Weapons Establishment awards Atos contract to support research ...

Atos launches world-first prescriptive Security Operations Center (SOC) with automated response ...

Four European supercomputing centres join forces in procurement process for innovative HPC systems ...

ELIXIR publishes its 2016 Annual Report ...

MareNostrum 4 begins operation ...

GÉANT appoints Erik Huizer as Interim CEO ...

Middleware

NEC accelerates machine learning for vector computers ...

Hardware

Argonne's Theta supercomputer goes online ...

Mellanox introduces Spectrum-2, world's most scalable 200 and 400 Gigabit Open Ethernet switch solution ...

June 2017 TOP500 list shows InfiniBand continues to be the interconnect of choice for high performance computing and Artificial Intelligence ...

Applications

Researchers at the University of Texas Medical Branch explore DNA folding, cellular packing with supercomputer simulations ...

NCSA grants $2.6 million in new Blue Waters supercomputer awards to Illinois researchers ...

NSF grants 14 researchers time on Blue Waters supercomputer ...

Great Lakes Consortium awards time on Blue Waters supercomputer ...

New data on the protective effects of Alzheimer's on Cancer ...

Will brain-inspired chips make a dent in science's Big Data problems? ...

IBM and Hortonworks expand partnership to help businesses accelerate data-driven decision making ...

ANDI project receives award for Amsterdam's most innovative scientific idea ...

Three-dimensional chip combines computing and data storage ...

University of Southern California to lead IARPA quantum computing project ...

Computing takes the prize ...

A new method for synthesising complex molecules ...

AI analyses X-rays as well as doctors ...

The Cloud

Maxeler Technologies to provide supercomputer performance to UK Government on the G-Cloud ...

NVIDIA and Baidu announce partnership to accelerate AI ...

New data on the protective effects of Alzheimer's on Cancer

3 Jul 2017 Barcelona - Patients with Alzheimer's disease have a higher risk of developing glioblastoma and a lower risk of lung cancer. A paper published inScientific Reportsby researchers from the Spanish National Cancer Research Centre (CNIO), headed by Alfonso Valencia, a researcher affiliated to the CNIO and to the Barcelona Supercomputing Center (BSC), describes the biological processes that underlie this comorbidity. In its new location at the BSC, Alfonso Valencia's group will be able to use large scale computing to continue the comorbidity work analyzing very large cohorts of patients and diseases at various levels.

The increase in life expectancy has resulted in many people developing multiple diseases. This phenomenon is known as comorbidity, and there may be a direct relationship, when in the presence of one pathology, there is a higher risk of another emerging; or an inverse relationship, having a certain condition implies a lower risk of developing another. Epidemiology has identified a number of relationships of this type, such as a lower incidence of cancer in people with certain diseases that affect the central nervous system.

A paper published in 2014 in the journalPLoS Geneticsby researchers from the CNIO revealed that over-expressed genes in central nervous system diseases - Alzheimer's disease, Parkinson's disease and schizophrenia - were under-expressed in cancer - lung, colon, and prostate - and vice versa. Understanding the molecular bases of these processes provides important information regarding the study of the causes of each disease and the possible design of new therapeutic strategies - drug repositioning.

The paper published now inScientific Reportsdelves into the relationship between Alzheimer's disease and brain tumours - glioblastoma, in particular, using lung cancer data as reference and applying a new meta-analytical method explicitly developed for this case.

"The analysis of glioblastoma, which has a direct comorbidity link with Alzheimer's and which, in addition, originates in the same organ, has allowed us to better understand the molecular relationships between Alzheimer's disease and cancer, and to eliminate tissue-dependent bias", stated Jon Sánchez-Valle, leading author of the paper.

The analyses conducted on more than 1000 samples from patients with these diseases have identified 198 genes whose function is altered significantly in the three cases. Of these, 112 had a similar pattern in Alzheimer's disease and glioblastoma and the opposite pattern in lung cancer.

By comparing the biological processes altered through the deregulation of these genes, the authors confirmed that mitochondrial dysfunction plays a key role in the development of Alzheimer's and could also lead to an increased risk of brain tumours in patients with Alzheimer's disease, through the emergence of chronic inflammation in the brain. The decrease in the energy supply and the generation of reactive oxygen species (ROS) due to alterations in the mitochondrial function would, in turn, be related to the protection against lung cancer in patients with Alzheimer's disease.

These results, the authors point out, could help in the search for new uses for existing drugs and new therapeutic combinations to treat these diseases based on patient-specific genomic information.

This research has been funded by the Spanish Ministry of Economy and Competitiveness (BIO2012-40205 and BFU2015-71241-R) and it was carried out in the framework of the Platform for Biomolecular and Bioinformatics Resource (PT13/0001/0030 of the ISCIII), which is funded through the European Regional Development Fund (ERDF). RT-S acknowledges funding from the Generalitat Valenciana (PROMETEOII/2015/021) and the national grant PI14/00894 from the Spanish "Plan Nacional de I + D + I 2013-2016", co-funded by the "ISCIII Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional" (FEDER).

Sánchez-Valle J., Tejero H., Ibáñez K., Portero J.L., Krallinger M., Al-Shahrour F., Tabarés-Seisdedos R., Baudot A., and Valencia A. are the authors of the paper titled " A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer ". The paper has been published online inScientific Reportson 30 June 2017 - doi:10.1038/s41598-017-04400-6.
Source: Barcelona Supercomputing Center - BSC

Back to Table of contents

Primeur weekly 2017-07-10

Focus

ELIXIR is working hard trying to find a common Key Performance Indicator vocabulary between research infrastructures ...

HPC in Asia - Status report from China ...

Quantum computing

Atos launches the highest-performing quantum simulator in the world ...

New method could enable more stable and scalable quantum computing, Penn physicists report ...

Focus on Europe

UK Atomic Weapons Establishment awards Atos contract to support research ...

Atos launches world-first prescriptive Security Operations Center (SOC) with automated response ...

Four European supercomputing centres join forces in procurement process for innovative HPC systems ...

ELIXIR publishes its 2016 Annual Report ...

MareNostrum 4 begins operation ...

GÉANT appoints Erik Huizer as Interim CEO ...

Middleware

NEC accelerates machine learning for vector computers ...

Hardware

Argonne's Theta supercomputer goes online ...

Mellanox introduces Spectrum-2, world's most scalable 200 and 400 Gigabit Open Ethernet switch solution ...

June 2017 TOP500 list shows InfiniBand continues to be the interconnect of choice for high performance computing and Artificial Intelligence ...

Applications

Researchers at the University of Texas Medical Branch explore DNA folding, cellular packing with supercomputer simulations ...

NCSA grants $2.6 million in new Blue Waters supercomputer awards to Illinois researchers ...

NSF grants 14 researchers time on Blue Waters supercomputer ...

Great Lakes Consortium awards time on Blue Waters supercomputer ...

New data on the protective effects of Alzheimer's on Cancer ...

Will brain-inspired chips make a dent in science's Big Data problems? ...

IBM and Hortonworks expand partnership to help businesses accelerate data-driven decision making ...

ANDI project receives award for Amsterdam's most innovative scientific idea ...

Three-dimensional chip combines computing and data storage ...

University of Southern California to lead IARPA quantum computing project ...

Computing takes the prize ...

A new method for synthesising complex molecules ...

AI analyses X-rays as well as doctors ...

The Cloud

Maxeler Technologies to provide supercomputer performance to UK Government on the G-Cloud ...

NVIDIA and Baidu announce partnership to accelerate AI ...