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Primeur weekly 2013-07-22

Special

Moore's Law is bound to continue but the formula for success is changing ...

The Cloud

Contrail project team to organize Contest Competition at Euro-Par 2013 ...

European Commission to issue report on Cloud Computing SLAs in FP7 ...

VEP 2.0 is now available ...

HP helps enterprises use Big Data to protect critical information and mitigate risk ...

HP helps DreamWorks Animation’s "Turbo" race into theaters ...

IBM announces a 10-year strategic partnership with UniCredit to deliver new services ...

Big Data from Alzheimer's disease whole genome sequencing will be available to researchers due to novel global research database ...

Desktop Grids

Italian BOINC project publishes research paper ...

EuroFlash

Tenders for the largest supercomputer in Poland are getting off the ground ...

Altair's Compute Manager 12.0 scales beyond 500 concurrent users and 500,000 jobs, managing Big Data from HPC faster ...

Absolute technologies is the latest Calibre UK distributoA ...

4K 3D transatlantic transmission streamed between Poznan and Chicago ...

PRACE demonstrates again its strong support for European high-impact science and innovation ...

USFlash

Internationally recognised computing experts augment NeSI team ...

LLNL High Performance Computing Innovation Center marks second anniversary ...

PGI Accelerator compilers add support for AMD APUs and GPUs ...

Rogue Wave and Cray Inc. expand strategic alliance ...

NWSC named 'green' data centre of the year ...

WildPackets announces WatchPoint 3.0 ...

Upsite Technologies joins the Green Grid to promote data centre efficiency through proper airflow management ...

NVIDIA launches world's first GPU-accelerated platform for geospatial intelligence analysts ...

Oracle Exalytics X3-4 powers real-time analytical insights ...

Computer system automatically generates TCP congestion-control algorithms ...

Strata Health helps customers speed patient care with Oracle Database Appliance ...

Big Data from Alzheimer's disease whole genome sequencing will be available to researchers due to novel global research database

12 Jul 2013 Boston - The Alzheimer's Association and the Brin Wojcicki Foundation announced that massive amounts of new data have been generated by the first "Big Data" project for Alzheimer's disease. The data will be made freely available to researchers worldwide to quickly advance Alzheimer's science.

Discussed at the Alzheimer's Association International Conference (AAIC) 2013 in Boston, the project obtained whole genome sequences on the largest cohort of individuals related to a single disease - more than 800 people enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI).

The genome sequencing data - estimated to be 200 terabytes - will be housed in and available through the Global Alzheimer's Association Interactive Network (GAAIN), a planned massive network of Alzheimer's disease research data made available by the world's foremost Alzheimer's researchers from their own laboratories, and which also has been publicly announced at AAIC 2013. GAAIN is funded by an initial $5 million dollar investment by the Alzheimer's Association, made possible due to the generous support of donors.

"The Alzheimer's Association is committed to creating open access to research data, and we believe GAAIN will transform how neuroscience data is shared and accessed by scientists throughout the world", stated Maria Carrillo, Ph.D., Alzheimer's Association vice president of Medical and Scientific Relations. "By fostering a higher level of global data sharing, GAAIN will accelerate investigation and discovery in Alzheimer's through a system comparable to a search engine like Google or Bing for relevant data."

"With the addition of more than 800 whole genomes on ADNI subjects that can be linked to the current rich dataset, ADNI data will be even more useful to scientists who are seeking new approaches to treatment and prevention of Alzheimer's disease", stated Robert C. Green, M.D., M.P.H., of Brigham and Women's Hospital and Harvard Medical School, who led the ADNI sequencing project. "ADNI is a leader in open data sharing, having provided clinical, imaging and biomarker data to over 4,000 qualified scientists around the world, which has generated over 700 scientific manuscripts.

Whole genome sequencing determines all six billion letters in an individual's DNA in one comprehensive analysis. The raw data from the ADNI project is being made available to qualified scientists around the globe to mine for novel targets for risk assessment, new therapies, and much-needed insight into the causes of the fatal brain disease. The new data may enable scientists to better understand how our genes cause and are affected by bodily changes associated with Alzheimer's disease.

ADNI enrolls people with Alzheimer's disease, mild cognitive impairment, and normal cognition who have agreed to be studied in great detail over time. The goal is to identify and understand markers of the disease in body fluids, structural changes in the brain, and measures of memory; the hope is to improve early diagnosis and accelerate the discovery of new treatments. ADNI is led by Principal Investigator Michael W. Weiner, M.D., of the University of California San Francisco and the San Francisco VA Medical Center. Dr. Green collaborated on managing the sequencing efforts with Arthur Toga, Ph.D., of UCLA and Andrew J. Saykin, Psy.D., of Indiana University. The actual genome sequencing was performed at Illumina Inc.

ADNI is a public-private research project led by the National Institutes of Health (NIH) with private sector support through the Foundation for NIH. Launched in 2004, ADNI's public-private funding consortium includes pharmaceutical companies, science-related businesses, and non-profit organisations including the Alzheimer's Association and the Northern California Institute for Research and Education.

Data-sharing has already greatly benefitted scientific disciplines such as genetics, molecular biology, and the physical sciences. Data-sharing in genetics has led to dramatic advances in understanding the risk factors underlying complex diseases. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a compelling example of dozens of geographically-dispersed researchers working together to share their data while making it freely available to others for analysis and publication.

"GAAIN is similar in spirit and goals to other 'big data' initiatives that seek to greatly improve the tools and techniques needed to access, organize, and make discoveries from huge volumes of digital data", Maria Carrillo stated. "The advent of Cloud computing makes it possible to link databases throughout the world and expand their data processing capability significantly to benefit the research community."

Maria Carrillo will supervise the development of GAAIN in conjunction with co-principal investigators Art Toga, Ph.D., of the Laboratory of Neuro Imaging (LONI) at the University of Southern California and Giovanni Frisoni, M.D., of the National Center for Alzheimer's Disease Research and Care and the Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fatebenefratelli Hospital, Italy. Enrique Castro-Leon, Ph.D., who will serve as a consultant, is an enterprise and data centre architect for strategic partner Intel Digital Enterprise Group.

GAAIN is built on an international database framework already in use by thousands of scientists and local computational facilities in North America and Europe. The network makes research data available free-of-charge for searching, downloading, and processing across a Cloud-based, Grid-network infrastructure accessible anywhere through Internet access.

The key to GAAIN's innovation is its federation of data, which is unprecedented for such a system. GAAIN leadership will invite scientists conducting qualified studies to become partners by permitting GAAIN to link directly to their databases. This will enable researchers to add continually to their data sets and keep all data in GAAIN current and dynamic. It also will enable the scientists to retain control over access to their data, which the Association believes will be important to encouraging participation.

"This is unprecedented and of the utmost importance in brain research, where sometimes thousands of examples are required to observe even the smallest change in the brain", stated Giovanni Frisoni, M.D., neurologist and deputy scientific director at the National Center for Alzheimer's Disease Research and Care at the IRCCS. He will lead the work of GAAIN in Europe.

"Through GAAIN we envision combining massive amounts of data from multiple sources across many subjects participating in numerous studies", stated Art Toga, Ph.D., professor of neurology at UCLA and director of LONI. "This will provide more statistical power than ever before."
Source: Alzheimer's Association

Back to Table of contents

Primeur weekly 2013-07-22

Special

Moore's Law is bound to continue but the formula for success is changing ...

The Cloud

Contrail project team to organize Contest Competition at Euro-Par 2013 ...

European Commission to issue report on Cloud Computing SLAs in FP7 ...

VEP 2.0 is now available ...

HP helps enterprises use Big Data to protect critical information and mitigate risk ...

HP helps DreamWorks Animation’s "Turbo" race into theaters ...

IBM announces a 10-year strategic partnership with UniCredit to deliver new services ...

Big Data from Alzheimer's disease whole genome sequencing will be available to researchers due to novel global research database ...

Desktop Grids

Italian BOINC project publishes research paper ...

EuroFlash

Tenders for the largest supercomputer in Poland are getting off the ground ...

Altair's Compute Manager 12.0 scales beyond 500 concurrent users and 500,000 jobs, managing Big Data from HPC faster ...

Absolute technologies is the latest Calibre UK distributoA ...

4K 3D transatlantic transmission streamed between Poznan and Chicago ...

PRACE demonstrates again its strong support for European high-impact science and innovation ...

USFlash

Internationally recognised computing experts augment NeSI team ...

LLNL High Performance Computing Innovation Center marks second anniversary ...

PGI Accelerator compilers add support for AMD APUs and GPUs ...

Rogue Wave and Cray Inc. expand strategic alliance ...

NWSC named 'green' data centre of the year ...

WildPackets announces WatchPoint 3.0 ...

Upsite Technologies joins the Green Grid to promote data centre efficiency through proper airflow management ...

NVIDIA launches world's first GPU-accelerated platform for geospatial intelligence analysts ...

Oracle Exalytics X3-4 powers real-time analytical insights ...

Computer system automatically generates TCP congestion-control algorithms ...

Strata Health helps customers speed patient care with Oracle Database Appliance ...