Back to Table of contents

Primeur weekly 2020-06-29

Quantum computing

Atos takes the most powerful quantum simulator in the world to the next level with Atos QLM E ...

New model helps to describe defects and errors in quantum computers ...

Research and Markets to issue 2020 Revenue Assessment for Post-Quantum Cryptography (PQC) report ...

Focus on Europe

Iceland joined the LUMI consortium ...

LRZ to deploy HPE's Cray CS500 system to bring innovative architecture to the science of its users ...

Outcome of the e-IRG Webinar Series organized in the framework of the Croatian EU Presidency on 25-26 May 2020: Grand challenges of e-infrastructures within the new ERA ...

Spring 2020 edition of the e-IRG Magazine available ...

MareNostrum will generate a language model in Spanish based on millions of digital contents from the National Library of Spain ...

A team of bioengineering and computing experts outlines how the creation of text mining and Artificial Intelligence tools could advance biomaterials research and development ...

Barcelona Supercomputing Center releases OmpSs-2 version 2020.06 ...

Barcelona Supercomputing Center releases COMPSs version 2.7 ...

Ghent University engages Atos to build third Tier1 VSC supercomputer supporting research in Flanders ...

Dell Technologies high performance computing customers drive breakthroughs for global impact ...

Hardware

NCSA and Southern Methodist University announce new strategic partnership ...

TYAN brings the latest server advancements at its 2020 Server Solutions Online Exhibition ...

WekaIO awarded a patent for Flash Registry with Write Leveling ...

Western Digital's New NVMe SSDs and NVMe-oF solutions provide the foundation for next-generation, agile data infrastructures ...

CW-WDM MSA Group forms to drive new industry standard for optical laser sources ...

Battelle awarded contract to enable Arctic research ...

Applications

Project to calculate emissions reductions across Europe during the COVID-19 pandemic ...

Supercomputer simulations show how DNA prepares itself for repair ...

Georgia Tech engineers simulate solar cell work using supercomputers ...

A new way of designing global satellite missions ...

Process for 'two-faced' nanomaterials may aid energy, information tech ...

New transatlantic lab decodes the brain with AI ...

Ion conducting polymer crucial to improving neuromorphic devices ...

Scientists develop new tool to design better fusion devices ...

C3.ai Digital Transformation Institute announces COVID-19 awards ...

UCF Consortium announces OpenSNAPI project to develop an open, standard application programming interface for smart networking adapters ...

The Cloud

SDSC's Sherlock Cloud announces Skylab ...

Dell Technologies brings IT infrastructure and Cloud capabilities to Edge environments ...

New technique may enable all-optical data-centre networks ...

Schrödinger expands discovery efforts for COVID-19 Alliance with advanced molecular simulation leveraging high-powered parallel computing on Google Cloud ...

Nebulon emerges from stealth and announces Cloud-Defined Storage ...

Repertoire Immune Medicines receives funding from COVID-19 High Performance Computing Consortium ...

W3BCLOUD raises $20,5 million to roll out a network of data centres dedicated for the blockchain economy ...

Repertoire Immune Medicines receives funding from COVID-19 High Performance Computing Consortium


Daniel Pregibon, PhD, SVP, Head of Platform Discovery and Technology, Repertoire Immune Medicines
24 Jun 2020 Cambridge - Repertoire Immune Medicines, a clinical-stage biotech company tooled to decode and deploy the immune system across multiple major diseases, has received funding from the COVID-19 High Performance Computing (HPC) Consortium, a private-public sector effort offering computing capabilities to support COVID-19 research programmes. Repertoire's research project aims to identify viral epitopes most likely to induce durable immunity to SARS-CoV-2, the virus that causes COVID-19, through induction of long-term memory in T cells. Under this grant, Repertoire will leverage the Cloud computing resources of Amazon Web Service (AWS) to simulate and predict the complex immunological interactions across patient populations that lead to clearance of SARS-CoV-2.

The Consortium-supported research project will combine Repertoire's state-of-the-art experimental platform, which measures T Cell Receptor (TCR)-antigen interactions at single-cell resolution, and then simulates these interactions on AWS. The goal is to identify those SARS-CoV-2 epitopes that have the highest likelihood of inducing long-term immunity when delivered through vaccines.

Long-term protection requires the development of T cell memory. Unlike antibodies, T cells find those cells infected by a virus such as COVID-19 by identifying virus-derived antigen molecules (epitopes) displayed on the surface of infected cells through their TCR, and then kill those cells and orchestrate a productive, long-term immune response.

"The dynamics of SARS-CoV-2 infection is yet to be fully understood, and it is unknown whether patients acquire long-term immunity to the virus following initial infection", stated Daniel Pregibon, Ph.D., SVP, Head of Platform Discovery and Technology, Repertoire Immune Medicines. "The majority of current investigations into COVID-19 vaccines focus on the B cell derived antibody responses to a handful of viral targets, typically those derived from the spike, membrane and nucleocapsid proteins. Our immune decoding capabilities have the potential to identify antigen molecules that induce a robust T cell response for inclusion in vaccines, and reveal the key to long-term immunity resulting from responses to any protein of SARS-CoV-2, or other cross-reactive coronaviruses, which will significantly expand the scope of vaccine development."

Through prior decoding of numerous T cell receptor-antigen interactions in high-performance computing environments, Repertoire has already operationalized the underlying experimental biology and computational infrastructure necessary to begin this project. The company intends to submit a manuscript for publication in a peer-reviewed journal shortly after project completion.

Source: Repertoire Immune Medicines

Back to Table of contents

Primeur weekly 2020-06-29

Quantum computing

Atos takes the most powerful quantum simulator in the world to the next level with Atos QLM E ...

New model helps to describe defects and errors in quantum computers ...

Research and Markets to issue 2020 Revenue Assessment for Post-Quantum Cryptography (PQC) report ...

Focus on Europe

Iceland joined the LUMI consortium ...

LRZ to deploy HPE's Cray CS500 system to bring innovative architecture to the science of its users ...

Outcome of the e-IRG Webinar Series organized in the framework of the Croatian EU Presidency on 25-26 May 2020: Grand challenges of e-infrastructures within the new ERA ...

Spring 2020 edition of the e-IRG Magazine available ...

MareNostrum will generate a language model in Spanish based on millions of digital contents from the National Library of Spain ...

A team of bioengineering and computing experts outlines how the creation of text mining and Artificial Intelligence tools could advance biomaterials research and development ...

Barcelona Supercomputing Center releases OmpSs-2 version 2020.06 ...

Barcelona Supercomputing Center releases COMPSs version 2.7 ...

Ghent University engages Atos to build third Tier1 VSC supercomputer supporting research in Flanders ...

Dell Technologies high performance computing customers drive breakthroughs for global impact ...

Hardware

NCSA and Southern Methodist University announce new strategic partnership ...

TYAN brings the latest server advancements at its 2020 Server Solutions Online Exhibition ...

WekaIO awarded a patent for Flash Registry with Write Leveling ...

Western Digital's New NVMe SSDs and NVMe-oF solutions provide the foundation for next-generation, agile data infrastructures ...

CW-WDM MSA Group forms to drive new industry standard for optical laser sources ...

Battelle awarded contract to enable Arctic research ...

Applications

Project to calculate emissions reductions across Europe during the COVID-19 pandemic ...

Supercomputer simulations show how DNA prepares itself for repair ...

Georgia Tech engineers simulate solar cell work using supercomputers ...

A new way of designing global satellite missions ...

Process for 'two-faced' nanomaterials may aid energy, information tech ...

New transatlantic lab decodes the brain with AI ...

Ion conducting polymer crucial to improving neuromorphic devices ...

Scientists develop new tool to design better fusion devices ...

C3.ai Digital Transformation Institute announces COVID-19 awards ...

UCF Consortium announces OpenSNAPI project to develop an open, standard application programming interface for smart networking adapters ...

The Cloud

SDSC's Sherlock Cloud announces Skylab ...

Dell Technologies brings IT infrastructure and Cloud capabilities to Edge environments ...

New technique may enable all-optical data-centre networks ...

Schrödinger expands discovery efforts for COVID-19 Alliance with advanced molecular simulation leveraging high-powered parallel computing on Google Cloud ...

Nebulon emerges from stealth and announces Cloud-Defined Storage ...

Repertoire Immune Medicines receives funding from COVID-19 High Performance Computing Consortium ...

W3BCLOUD raises $20,5 million to roll out a network of data centres dedicated for the blockchain economy ...