Back to Table of contents

Primeur weekly 2017-04-10

Exascale supercomputing

EUROSERVER paves the way for low-power data centres ...

Intersect360 Research to provide USCC testimony for China's Pursuit of Next Frontier Tech hearing ...

Quantum computing

'Virtual' interferometers may overcome scale issues for optical quantum computers ...

Quantum-physical model system ...

Optics advance quantum information processing ...

Focus on Europe

A glance into the ISC 2017 Research Paper Session ...

OCF announce Iceotope as liquid cooling partner for research and academic market ...

Return of the mini-supercomputer in the Netherlands: Little Green Machine II ...

Max Planck Institute for Biophysical Chemistry chooses vSMP Foundation ...

PRACE opens SHAPE 5th Call for Proposals ...

IBM invests to accelerate innovation, collaboration and fast-track health care solutions in Finland ...

73% of academics say access to research data helps them in their work; 34% do not publish their data ...

Middleware

DDN Lustre powers University of Edinburgh accelerated genomics research ...

Hardware

Supercomputer growth drives record HPC revenue in 2016, Hyperion Research reports ...

Canada's most powerful academic supercomputer will launch at Simon Fraser University ...

Silicon Mechanics Announces Recipient of 6th Annual Research Cluster Grant ...

U.S. businesses risk falling behind as lead in global semiconductor industry threatened ...

Fujitsu and Oracle launch Fujitsu SPARC M12 servers with world's fastest per-core performance ...

IBM Researchers advance the understanding of chip reliability at IEEE International Reliability Physics Symposium ...

Applications

Artificial intelligence: Bosch and University of Amsterdam to cooperate closely ...

Cyber gene network could speed up discoveries ...

How can network analysis lead to a new way of studying court decisions? ...

IBM patents machine learning models for drug discovery ...

Clemson scientists receive $2.95 million to improve and simplify large-scale data analysis ...

New brain-inspired cybersecurity system detects 'bad apples' 100 times faster ...

Supercomputers reveal how cell membranes keep cancer-causing proteins turned off ...

The Cloud

IBM opens Budapest Software Lab to develop Cloud Video solutions ...

IBM first to deliver latest NVIDIA GPU accelerator on the Cloud to speed AI workloads ...

University of Wyoming uses Oracle Cloud to drive core mission of teaching, research, and service ...

Industry experts discuss advantages and risks of shifting data analytics to the Cloud ...

IBM patents machine learning models for drug discovery


IBM Research staff member Ping Zhang (left) and Programme Director, Center for Computational Health Jianying Hu (right) with their newly patented invention to help drug discovery researchers identify which drug indications are typically linked to which side effects.
7 Apr 2017 Armonk - IBM's scientists have been granted a patent on machine learning models to predict therapeutic indications and side effects from various drug information sources. IBM Research has implemented a cognitive association engine to identify significant linkages between predicted therapeutic indications and side effects, and a visual analytics system to support the interactive exploration of these associations.

This approach could help researchers in pharmaceutical companies to generate hypotheses for drug discovery. For instance, strongly correlated disease-side-effect pairs identified by the patented invention could be beneficial for drug discovery in many ways. One could use the side-effect information to repurpose existing treatments, e.g. drugs causing postural hypotension could be potential candidates for treating hypertension. If a new drug is being designed for a disease that is strongly correlated with severe side effects, then special attention could be paid to controlling the formulation and dosing of the drug in the clinical trials to prevent serious safety issues.

IBM was granted U.S. Patent 9,536,194: Method and system for exploring the associations between drug side-effects and therapeutic indications for this invention.

Lack of efficacy and adverse side effects are two of the primary reasons a drug fails clinical trials, each accounting for around 30 percent of failures. Computational models and machine learning methods that can derive useful insights from large amounts of data on drugs and diseases from various sources hold great promise for reducing these attrition rates and improving the drug discovery process.

"As inventors at IBM, we have the opportunity to help solve real-world problems", stated Jianying Hu, Senior Manager and Programme Director, Center for Computational Health, IBM Research. "Our team is dedicated to this research and we continue to search for new ways to improve people’s health around the world through innovation and invention."

One of the research areas of the Center for Computational Health at IBM Thomas J. Watson Research Center is translational informatics, which focuses on the development of novel techniques to extract insights and knowledge from biological and clinical data to support biological scientists, clinicians, and patients.

IBM has been working in this area for several years, and has developed a suite of advanced machine learning tools as well as computational models and platforms that can be used to derive insights from a wide variety of data sources, e.g. pharmacological knowledge bases, to help improve the efficiency and effectiveness of drug discovery and development. These methodologies have been applied to many specific use cases including drug repurposing, i.e. helping to find new uses for existing drugs in the market; indication expansion, i.e. helping to identify potential new indications for drugs still in various stages of a development pipeline; drug safety, i.e. helping to detect and predict a drug's safety profiles; and personalized medicine, e.g. personalized efficacy/safety profile predictions.
Source: IBM

Back to Table of contents

Primeur weekly 2017-04-10

Exascale supercomputing

EUROSERVER paves the way for low-power data centres ...

Intersect360 Research to provide USCC testimony for China's Pursuit of Next Frontier Tech hearing ...

Quantum computing

'Virtual' interferometers may overcome scale issues for optical quantum computers ...

Quantum-physical model system ...

Optics advance quantum information processing ...

Focus on Europe

A glance into the ISC 2017 Research Paper Session ...

OCF announce Iceotope as liquid cooling partner for research and academic market ...

Return of the mini-supercomputer in the Netherlands: Little Green Machine II ...

Max Planck Institute for Biophysical Chemistry chooses vSMP Foundation ...

PRACE opens SHAPE 5th Call for Proposals ...

IBM invests to accelerate innovation, collaboration and fast-track health care solutions in Finland ...

73% of academics say access to research data helps them in their work; 34% do not publish their data ...

Middleware

DDN Lustre powers University of Edinburgh accelerated genomics research ...

Hardware

Supercomputer growth drives record HPC revenue in 2016, Hyperion Research reports ...

Canada's most powerful academic supercomputer will launch at Simon Fraser University ...

Silicon Mechanics Announces Recipient of 6th Annual Research Cluster Grant ...

U.S. businesses risk falling behind as lead in global semiconductor industry threatened ...

Fujitsu and Oracle launch Fujitsu SPARC M12 servers with world's fastest per-core performance ...

IBM Researchers advance the understanding of chip reliability at IEEE International Reliability Physics Symposium ...

Applications

Artificial intelligence: Bosch and University of Amsterdam to cooperate closely ...

Cyber gene network could speed up discoveries ...

How can network analysis lead to a new way of studying court decisions? ...

IBM patents machine learning models for drug discovery ...

Clemson scientists receive $2.95 million to improve and simplify large-scale data analysis ...

New brain-inspired cybersecurity system detects 'bad apples' 100 times faster ...

Supercomputers reveal how cell membranes keep cancer-causing proteins turned off ...

The Cloud

IBM opens Budapest Software Lab to develop Cloud Video solutions ...

IBM first to deliver latest NVIDIA GPU accelerator on the Cloud to speed AI workloads ...

University of Wyoming uses Oracle Cloud to drive core mission of teaching, research, and service ...

Industry experts discuss advantages and risks of shifting data analytics to the Cloud ...