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Primeur weekly 2020-03-23

Crowd computing

Crowdsourced supercomputing project sets sights on coronavirus ...

Focus on Europe

LEXIS: novel computing systems at IT4Innovations and Leibniz Rechenzentrum (LRZ) ...

Exscalate4CoV supercomputing platform wins 3 million euro EU funding to hunt for new drugs against coronavirus pandemic ...

Open collaborative infrastructure to tackle public health emergencies ...

AMPERE Project: Strengthening European leadership in energy-efficiency and parallel computing ...

The European Commission offers significant support to Europe's AI excellence ...

Middleware

Atipa Technologies becomes the latest organisation to join the Bright Reseller Programme in North America ...

Hardware

Rittal announces its first HPC Direct Chip Cooling solution with ZutaCore ...

Intel scales neuromorphic research system to 100 million neurons ...

COVID-19 to have significant effect on worldwide semiconductor market in 2020, according to IDC ...

Foundry revenue estimated to grow by 30% YoY in 1Q20, while COVID-19 pandemic may hinder future market demand, according to TrendForce ...

MEGWARE to provide IBM Power in its Benchmark Center ...

Rescale partners with Google Cloud and Microsoft Azure to accelerate the race for COVID-19 vaccine with Cloud supercomputers for researchers ...

Applications

Cadence digital full flow optimized to deliver improved quality of results with up to 3x faster throughput ...

Supercomputers unlock reproductive mysteries of viruses and life ...

RIKEN is exploring the molecular dynamics of the new coronavirus ...

Rensselaer offers AiMOS supercomputing capabilities to battle COVID-19 ...

Scientists discover critical protein that lets COVID-19 virus hide from immune system ...

NVIDIA gives COVID-19 researchers free access to Parabricks ...

Pioneers of modern computer graphics recognized with ACM A.M. Turing Award ...

Data Science Institute alumni use machine learning to discover coronavirus treatments ...

Berkeley lab cosmologists are top contenders in machine learning challenge ...

New satellite-based algorithm pinpoints crop water use ...

Northern Data announces revenue and earnings forecast for 2020 ...

The Cloud

Qumulo offers free Cloud software to help medical and health care research organisations fight the COVID-19 outbreak ...

Scientists discover critical protein that lets COVID-19 virus hide from immune system

20 Mar 2020 Chicago - A new potential drug target has been identified in SARS CoV-2 - the virus that causes COVID-19 — by scientists who say multiple drugs will be needed to treat the pandemic.

Scientists from Northwestern University Feinberg School of Medicine have mapped the atomic structure of two critical proteins in a complex, nsp10/16. These proteins modify the genetic material of the virus to make it look more like the host (human) cell RNA.

This allows the virus to hide from the cells, giving it time to multiply. If a drug can be developed to inhibit nsp10/nsp16, the immune system should be able to detect the virus and eradicate it faster.

"This is a really beautiful target, because it’s a protein absolutely essential for the virus to replicate", stated lead investigator Karla Satchell.

Karla Satchell is a professor of microbiology-immunology at Northwestern and director of Center for Structural Genomics of Infectious Diseases (CSGID), an international consortium of scientists who are investigating the structure of the virus to aid drug development.

Kara Satchell's team is sending the new protein to Purdue University, the drug-discovery site of the centre, to be screened for novel inhibitors that could be developed as new drugs.

The nsp10/nsp16 protein is called an RNA methyltransferase or MTase. It is comprised of two proteins bound together, which makes it more difficult to work with. The association of the two pieces together is required to make a functional protein, according to prior research on SARS.

The structure of nsp10/16 was released to the scientific community March 18 on the RSCB Protein Data Bank .

This is the fourth protein structure of potential drug target of SARS-CoV-2 determined by the CSGID team of scientists.

"We need multiple drugs to treat this virus, because this disease is likely to be with us for a long time", Karla Satchell stated. ​"It's not good enough for us to develop a single drug. If COVID-19 develops a resistance to one drug, then we need others."

Structures of three other proteins important for the replication of the virus were also released: the nsp15 endonuclease, nsp3 ADP ribose phosphate and nsp9 replicase. These structures were determined by the centre scientists at University of Chicago headed by professor Andrzej Joachimiak, Distinguished Fellow at the U.S. Department of Energy's (DOE) Argonne National Laboratory, who also is an adjunct professor at Northwestern. All work conducted by both the University of Chicago and Northwestern teams was designed by the bioinformatic team of Adam Godzik at the University of California at Riverside based on research conducted on SARS.

The centre is racing to release more structures for drug development. The centre's goal is to determine structures of all of the proteins that are potential drug targets. The team also is collaborating to provide proteins to investigators for design of improved vaccines.

Data for this structure was collected at the Northwestern managed Life Sciences Collaborative Access Team beamline at the Advanced Photon Source (APS) at Argonne. The LS-CAT staff worked quickly with APS and Karla Satchell to provide rapid access to the beamline over a weekend specifically to collect data for this project.

"The centre has shown a great ability to bring structure biology to the scientific community at an unprecedented rate", Karla Satchell stated. But their work has become more challenging because so many universities have reduced activities and some labs have shut down entirely.

"Our ability to do experiments is abating", Karla Satchell stated. Still, the center will continue to release new structures until they reach their goal, she said.

The CSGID is funded as a contract from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), in part to serve as a response site to conduct structure biology research in the event of an unexpected infectious disease outbreak. The NIAID has been working closely with the Center since early January to coordinate center activities with other research supported by NIAID and to share information from the center with NIAID personnel specializing in drug discovery.

This study has been funded by contract HHSN272201700060C from the National Institute of Allergy and Infectious Diseases of the NIH.
Source: Argonne National Laboratory

Back to Table of contents

Primeur weekly 2020-03-23

Crowd computing

Crowdsourced supercomputing project sets sights on coronavirus ...

Focus on Europe

LEXIS: novel computing systems at IT4Innovations and Leibniz Rechenzentrum (LRZ) ...

Exscalate4CoV supercomputing platform wins 3 million euro EU funding to hunt for new drugs against coronavirus pandemic ...

Open collaborative infrastructure to tackle public health emergencies ...

AMPERE Project: Strengthening European leadership in energy-efficiency and parallel computing ...

The European Commission offers significant support to Europe's AI excellence ...

Middleware

Atipa Technologies becomes the latest organisation to join the Bright Reseller Programme in North America ...

Hardware

Rittal announces its first HPC Direct Chip Cooling solution with ZutaCore ...

Intel scales neuromorphic research system to 100 million neurons ...

COVID-19 to have significant effect on worldwide semiconductor market in 2020, according to IDC ...

Foundry revenue estimated to grow by 30% YoY in 1Q20, while COVID-19 pandemic may hinder future market demand, according to TrendForce ...

MEGWARE to provide IBM Power in its Benchmark Center ...

Rescale partners with Google Cloud and Microsoft Azure to accelerate the race for COVID-19 vaccine with Cloud supercomputers for researchers ...

Applications

Cadence digital full flow optimized to deliver improved quality of results with up to 3x faster throughput ...

Supercomputers unlock reproductive mysteries of viruses and life ...

RIKEN is exploring the molecular dynamics of the new coronavirus ...

Rensselaer offers AiMOS supercomputing capabilities to battle COVID-19 ...

Scientists discover critical protein that lets COVID-19 virus hide from immune system ...

NVIDIA gives COVID-19 researchers free access to Parabricks ...

Pioneers of modern computer graphics recognized with ACM A.M. Turing Award ...

Data Science Institute alumni use machine learning to discover coronavirus treatments ...

Berkeley lab cosmologists are top contenders in machine learning challenge ...

New satellite-based algorithm pinpoints crop water use ...

Northern Data announces revenue and earnings forecast for 2020 ...

The Cloud

Qumulo offers free Cloud software to help medical and health care research organisations fight the COVID-19 outbreak ...