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Primeur weekly 2017-02-20

Focus

HPC expert Genias Benelux to show its skillful expertise in brandnew website ...

Are billion Euro Flagships the right way to finance innovative areas like graphene, human brain research and quantum computing? ...

Exascale supercomputing

Advanced fusion code led by PPPL selected to participate in Early Science Programmes on three new DOE Office of Science pre-exascale supercomputers ...

Focus on Europe

From robotics to particle physics: Data analytics gets the spotlight in Distinguished Talk series at ISC 2017 ...

A new spin on electronics ...

Data mining tools for personalized cancer treatment ...

Why host HPC in Iceland to tackle Big Data for life sciences at Earlham Insititute ...

Biological experiments become transparent - anywhere, any time ...

Middleware

IBM delivers new platform to help clients address storage challenges at massive scale ...

Hewlett Packard Enterprise unveils most significant 3PAR Flash storage innovations to date ...

Hardware

Tokyo Institute of Technology partners with DDN on Tsubame3.0 to build forward-looking AI and Big Data computing infrastructure ...

Mellanox demonstrates four times improvement in crypto performance with Innova IPsec 40G Ethernet network adapter ...

Supermicro launches BigTwin - the industry's highest performing Twin multi-node system supporting the full range of CPUs, maximum memory and all-flash NVMe ...

Applications

Researchers catch extreme waves with higher-resolution modelling ...

Researchers are creating software to 'clean' large datasets, making it easier for scientists and the public to use Big Data ...

Designing new materials from 'small' data ...

Success by deception ...

DNA computer brings 'intelligent drugs' a step closer ...

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices ...

Perimeter Institute researchers apply machine learning to condensed matter physics ...

When treating brain aneurysms, two isn't always better than one ...

Real-time MRI analysis powered by supercomputers ...

Analyzing data for transportation systems using TACC's Rustler, XSEDE ECSS support ...

NCSA facilitates performance comparisons with China's nr. 1 supercomputer ...

IBM delivers Watson for cyber security to power cognitive security operations centres ...

The Cloud

Optimizing data centre placement and network design to strengthen Cloud computing ...

Dutch start-up solution impacts data centres ...

OpenFog Consortium releases landmark reference architecture for Fog computing ...

IBM brings machine learning to the private Cloud ...

IBM accelerates hybrid Cloud adoption by enabling channel partners to offer VMware solutions ...

Oracle launches Cloud service to help organisations integrate disparate data and drive real-time analytics ...

DNA computer brings 'intelligent drugs' a step closer

17 Feb 2017 Eindhoven - Researchers at Eindhoven University of Technology (TU/e) present a new method that should enable controlled drug delivery into the bloodstream using DNA computers. Led by biomedical engineer Maarten Merkx the team developed the first DNA computer capable of detecting several antibodies in the blood and performing subsequent calculations based on this input. This is an important step towards the development of smart, 'intelligent' drugs that may allow better control of medication with fewer side-effects and at lower cost.

An analogy for the method presented by the TU/e researchers is a security system that opens the door depending on the person standing in front of it. If the camera recognizes the person, the door unlocks, but if the person is unknown, the door remains locked. "Research into diagnostic tests tends to focus on the 'recognition', but what is special about this system is that it can think and that it can be connected to actuation such as drug delivery", stated professor of Biomedical Chemistry Maarten Merkx.

To be able to perform such an action, 'intelligence' is needed, a role that is performed in this system by a DNA computer. DNA is best known as a carrier of genetic information, but DNA molecules are also highly suitable for performing molecular calculations. The sequence within a DNA molecule determines with which other DNA molecules it can react, which allows a researcher to program desired reaction circuits.

To date biomedical applications of DNA computers have been limited because the input of DNA computers typically consists of other DNA and RNA molecules. To determine whether someone has a particular disease, it is essential to measure the concentration of specific antibodies - agents that our immune system produces when we are ill. Maarten Merkx and his colleagues are the first to have succeeded in linking the presence of antibodies to a DNA computer.

Their method translates the presence of each antibody into a unique piece of DNA whereby the DNA computer can decide on the basis of the presence of one or more antibodies whether drug delivery, for example, is necessary. "The presence of a particular DNA molecule sets in motion a series of reactions whereby we can get the DNA computer to run various programmes", explained PhD student and primary author Wouter Engelen. "Our results show that we can use the DNA computer to control the activity of enzymes, but we think it should also be possible to control the activity of a therapeutic antibody."

In treating chronic diseases like rheumatism or Crohn's disease, such therapeutic antibodies are used as medication. One of the potential applications of this system is to measure the quantity of therapeutic antibodies in the blood and decide whether it is necessary to administer any extra medication. Maarten Merkx stated: "By directly linking the measurement of antibodies to the treatment of the disease, we may be able to prevent side-effects and reduce costs in the future."

Source: Eindhoven University of Technology

Back to Table of contents

Primeur weekly 2017-02-20

Focus

HPC expert Genias Benelux to show its skillful expertise in brandnew website ...

Are billion Euro Flagships the right way to finance innovative areas like graphene, human brain research and quantum computing? ...

Exascale supercomputing

Advanced fusion code led by PPPL selected to participate in Early Science Programmes on three new DOE Office of Science pre-exascale supercomputers ...

Focus on Europe

From robotics to particle physics: Data analytics gets the spotlight in Distinguished Talk series at ISC 2017 ...

A new spin on electronics ...

Data mining tools for personalized cancer treatment ...

Why host HPC in Iceland to tackle Big Data for life sciences at Earlham Insititute ...

Biological experiments become transparent - anywhere, any time ...

Middleware

IBM delivers new platform to help clients address storage challenges at massive scale ...

Hewlett Packard Enterprise unveils most significant 3PAR Flash storage innovations to date ...

Hardware

Tokyo Institute of Technology partners with DDN on Tsubame3.0 to build forward-looking AI and Big Data computing infrastructure ...

Mellanox demonstrates four times improvement in crypto performance with Innova IPsec 40G Ethernet network adapter ...

Supermicro launches BigTwin - the industry's highest performing Twin multi-node system supporting the full range of CPUs, maximum memory and all-flash NVMe ...

Applications

Researchers catch extreme waves with higher-resolution modelling ...

Researchers are creating software to 'clean' large datasets, making it easier for scientists and the public to use Big Data ...

Designing new materials from 'small' data ...

Success by deception ...

DNA computer brings 'intelligent drugs' a step closer ...

'Lossless' metamaterial could boost efficiency of lasers and other light-based devices ...

Perimeter Institute researchers apply machine learning to condensed matter physics ...

When treating brain aneurysms, two isn't always better than one ...

Real-time MRI analysis powered by supercomputers ...

Analyzing data for transportation systems using TACC's Rustler, XSEDE ECSS support ...

NCSA facilitates performance comparisons with China's nr. 1 supercomputer ...

IBM delivers Watson for cyber security to power cognitive security operations centres ...

The Cloud

Optimizing data centre placement and network design to strengthen Cloud computing ...

Dutch start-up solution impacts data centres ...

OpenFog Consortium releases landmark reference architecture for Fog computing ...

IBM brings machine learning to the private Cloud ...

IBM accelerates hybrid Cloud adoption by enabling channel partners to offer VMware solutions ...

Oracle launches Cloud service to help organisations integrate disparate data and drive real-time analytics ...