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Primeur weekly 2020-01-13

Focus

Ambitious plans for e-IRG, EOSC and EuroHPC under Croatian EU Presidency - Interview with Ivan Maric, SRCE, Croatia ...

Quantum computing

Delta partners with IBM to explore quantum computing - an airline industry first ...

IBM working with over 100 organisations to advance practical quantum computing ...

New quantum loop provides long national testbed for quantum communication technology ...

The case of the elusive Majorana: The so-called 'angel particle' is still a mystery ...

World's first quantum-safe connected car secured by ISARA ...

Georgia Tech collaborates with IBM to develop software stacks for quantum computers ...

New York University partners with IBM to explore quantum computing for simulation of quantum systems and advancing quantum education ...

Focus on Europe

Barcelona Supercomputing Center coordinates the manufacture of the first open source chip developed in Spain ...

Atos empowers researchers at the University of Luxembourg with its BullSequana XH2000 supercomputer ...

Solemn inauguration of the HLRN-IV system ...

The European Commission is looking for IT specialists in HPC, Quantum, Infrastructure and Cloud ...

Dr. Alice-Agnes Gabriel wins 2020 PRACE Ada Lovelace Award for HPC ...

Middleware

Altair acquires newFASANT, further expanding high-frequency electromagnetics portfolio ...

Hardware

ECMWF signs contract with Atos for new supercomputer ...

World High Performance Computing (HPC) markets to 2025 - AI, IoT, and 5G will be major drivers for HPC growth as they facilitate the need to process vast amounts of data ...

IDC MarketScape names WekaIO as a major player in file-based storage ...

200G HDR InfiniBand to accelerate the new European Centre for Medium-Range Weather Forecasts (ECMWF) supercomputer ...

Applications

Frederick National Laboratory part of SC19 "Best Paper" team ...

Hyperion Research expands its analyst team ...

Supercomputer simulations showcase novel planet formation models ...

Satellite constellations harvest energy for near-total global coverage ...

Exploring the 'dark side' of a single-crystal complex oxide thin film ...

Sublimation, not melting: Graphene surprises researchers again ...

Persistence of gut microbial strains in twins, living apart after cohabitating for decades ...

Kun Sun and Sushil Jajodia receive funding for subcontract agreement ...

Decrappifying brain images with deep learning ...

Xylem expands regional headquarters in Singapore with new Technology Hub ...

The Cloud

Intel brings innovation to life with intelligent tech spanning the Cloud, network, edge and PC at CES 2020 ...

Los Alamos National Laboratory joins IBM Q Network to explore quantum computing algorithms and education outreach ...

Persistence of gut microbial strains in twins, living apart after cohabitating for decades


Using a genomics strain-tracking bioinformatics tool, researchers investigated whether shared bacterial strains remain stable and resilient to changes in diet or environment after adult twins - who had lived together for decades - began to live apart. The study analyzed two metagenomic sequencing databases from pairs of twins - one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years. Credit: UA.
8 Jan 2020 Birmingham - Your fingerprints stay the same all your life. But what about the "fingerprint" of microbial strains that are shared in the guts of childhood twins?

Using a genomics strain-tracking bioinformatics tool developed at the University of Alabama at Birmingham (UAB), researchers investigated whether those shared bacterial strains remain stable and resilient to changes in diet or environment after adult twins - who had lived together for decades - began to live apart.

The UAB study, published in the journalPLOS ONE, analyzed two metagenomic sequencing databases from pairs of twins - one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years.

"Adult twins, ages 36 to 80 years old, showed that a certain strain or strains between a pair of twins was shared post-separation", stated Casey Morrow, Ph.D., professor emeritus in UAB's Department of Cell, Developmental and Integrative Biology. "While we do not know the origin of these shared microbes in the twins, these results suggest the possibility of strains shared between non-cohabitating twins for decades. As a corollary to these studies, our studies establish a time line for stability of microbial strains in the human gut."

The study used a strain-tracking bioinformatics tool previously developed by UAB, called Window-based Similarity Single-nucleotide-variant, or WSS. Hyunmin Koo, Ph.D., UAB Department of Genetics and Genomics Core, led the informatics analysis. The research generated about six terabytes of data, which was analyzed with the help of the Cheaha UABgrid supercomputer and the UAB Information Technology's Research Computing group.

Casey Morrow and colleagues have used this microbe fingerprint tool in several previous strain-tracking studies. In 2017, they found that fecal donor microbes - used to treat patients with recurrent Clostridium difficile infections - remained in recipients for months or years after fecal transplants. In 2018, they showed that changes in the upper gastrointestinal tract through obesity surgery led to the emergence of new strains of microbes, and in 2019, they analyzed the stability of new strains in individuals after antibiotic treatments.

The current study used metagenomic sequencing databases from fecal samples of eight twin child individuals and 50 twin adult individuals.

The UAB researchers found significantly more shared strain pairs in child-aged twins who still lived together, as compared with adult twins after living apart for periods of time. Among the adult twins, those who had lived apart less than 10 years shared significantly more related strain pairs than twins living apart for longer periods, from 10 to 60 years.

Specifically, 80-year-old twins who had lived together for 79 years then were apart for 1 year showed the highest number of related strain pairs. The next highest numbers of related strain pairs were found in 56-year-old twins who had lived together for 51 years then apart for five years, in 73-year-old twins who lived together for 66 years and then apart for seven years, and in 36-year-old twins separated for 19 years.

Single-shared strains were seen in three twin sets who had lived apart between 22 to 54 years, but these sporadic shared strains did not show a correlation with the length of living apart.

"While certain gut microbial strains can be stable in people, in some cases for decades, changes in the host environmental conditions over time can impact the stability landscape of the gut microbial community", Casey Morrow stated. "This might result in the appearance of new strains that could potentially impact the microbial interactions that are essential for function in human health."

Co-authors with Casey Morrow and Hyunmin Koo in the study, " Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades ", are Joseph A. Hakim, Department of Biology, UAB College of Arts and Sciences; David K. Crossman, UAB Department of Genetics and Genomics Core; and Elliot J. Lefkowitz, UAB Department of Microbiology.

Source: University of Alabama at Birmingham

Back to Table of contents

Primeur weekly 2020-01-13

Focus

Ambitious plans for e-IRG, EOSC and EuroHPC under Croatian EU Presidency - Interview with Ivan Maric, SRCE, Croatia ...

Quantum computing

Delta partners with IBM to explore quantum computing - an airline industry first ...

IBM working with over 100 organisations to advance practical quantum computing ...

New quantum loop provides long national testbed for quantum communication technology ...

The case of the elusive Majorana: The so-called 'angel particle' is still a mystery ...

World's first quantum-safe connected car secured by ISARA ...

Georgia Tech collaborates with IBM to develop software stacks for quantum computers ...

New York University partners with IBM to explore quantum computing for simulation of quantum systems and advancing quantum education ...

Focus on Europe

Barcelona Supercomputing Center coordinates the manufacture of the first open source chip developed in Spain ...

Atos empowers researchers at the University of Luxembourg with its BullSequana XH2000 supercomputer ...

Solemn inauguration of the HLRN-IV system ...

The European Commission is looking for IT specialists in HPC, Quantum, Infrastructure and Cloud ...

Dr. Alice-Agnes Gabriel wins 2020 PRACE Ada Lovelace Award for HPC ...

Middleware

Altair acquires newFASANT, further expanding high-frequency electromagnetics portfolio ...

Hardware

ECMWF signs contract with Atos for new supercomputer ...

World High Performance Computing (HPC) markets to 2025 - AI, IoT, and 5G will be major drivers for HPC growth as they facilitate the need to process vast amounts of data ...

IDC MarketScape names WekaIO as a major player in file-based storage ...

200G HDR InfiniBand to accelerate the new European Centre for Medium-Range Weather Forecasts (ECMWF) supercomputer ...

Applications

Frederick National Laboratory part of SC19 "Best Paper" team ...

Hyperion Research expands its analyst team ...

Supercomputer simulations showcase novel planet formation models ...

Satellite constellations harvest energy for near-total global coverage ...

Exploring the 'dark side' of a single-crystal complex oxide thin film ...

Sublimation, not melting: Graphene surprises researchers again ...

Persistence of gut microbial strains in twins, living apart after cohabitating for decades ...

Kun Sun and Sushil Jajodia receive funding for subcontract agreement ...

Decrappifying brain images with deep learning ...

Xylem expands regional headquarters in Singapore with new Technology Hub ...

The Cloud

Intel brings innovation to life with intelligent tech spanning the Cloud, network, edge and PC at CES 2020 ...

Los Alamos National Laboratory joins IBM Q Network to explore quantum computing algorithms and education outreach ...