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Primeur weekly 2020-01-13

Focus

Ambitious plans for e-IRG, EOSC and EuroHPC under Croatian EU Presidency - Interview with Ivan Maric, SRCE, Croatia ...

Quantum computing

Delta partners with IBM to explore quantum computing - an airline industry first ...

IBM working with over 100 organisations to advance practical quantum computing ...

New quantum loop provides long national testbed for quantum communication technology ...

The case of the elusive Majorana: The so-called 'angel particle' is still a mystery ...

World's first quantum-safe connected car secured by ISARA ...

Georgia Tech collaborates with IBM to develop software stacks for quantum computers ...

New York University partners with IBM to explore quantum computing for simulation of quantum systems and advancing quantum education ...

Focus on Europe

Barcelona Supercomputing Center coordinates the manufacture of the first open source chip developed in Spain ...

Atos empowers researchers at the University of Luxembourg with its BullSequana XH2000 supercomputer ...

Solemn inauguration of the HLRN-IV system ...

The European Commission is looking for IT specialists in HPC, Quantum, Infrastructure and Cloud ...

Dr. Alice-Agnes Gabriel wins 2020 PRACE Ada Lovelace Award for HPC ...

Middleware

Altair acquires newFASANT, further expanding high-frequency electromagnetics portfolio ...

Hardware

ECMWF signs contract with Atos for new supercomputer ...

World High Performance Computing (HPC) markets to 2025 - AI, IoT, and 5G will be major drivers for HPC growth as they facilitate the need to process vast amounts of data ...

IDC MarketScape names WekaIO as a major player in file-based storage ...

200G HDR InfiniBand to accelerate the new European Centre for Medium-Range Weather Forecasts (ECMWF) supercomputer ...

Applications

Frederick National Laboratory part of SC19 "Best Paper" team ...

Hyperion Research expands its analyst team ...

Supercomputer simulations showcase novel planet formation models ...

Satellite constellations harvest energy for near-total global coverage ...

Exploring the 'dark side' of a single-crystal complex oxide thin film ...

Sublimation, not melting: Graphene surprises researchers again ...

Persistence of gut microbial strains in twins, living apart after cohabitating for decades ...

Kun Sun and Sushil Jajodia receive funding for subcontract agreement ...

Decrappifying brain images with deep learning ...

Xylem expands regional headquarters in Singapore with new Technology Hub ...

The Cloud

Intel brings innovation to life with intelligent tech spanning the Cloud, network, edge and PC at CES 2020 ...

Los Alamos National Laboratory joins IBM Q Network to explore quantum computing algorithms and education outreach ...

Frederick National Laboratory part of SC19 "Best Paper" team


Photo courtesy of Lawrence Livermore National Laboratory.
7 Jan 2020 Frederick - A multidisciplinary team including members of the Frederick National Laboratory has been recognized with the "Best Paper" award at SC19, a prestigious international conference for high-performance computing, networking, storage, and analysis. Of the 344 papers submitted to SC19, only 87 were accepted, and just one was named Best Paper.

The research team spent more than two years working on their project, the second pilot arm of an initiative known as the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C). This collaboration, which began in 2016, hopes to accelerate cancer research by using cutting-edge high-performance computing.

Titled "Massively Parallel Infrastructure for Adaptive Multiscale Simulations: Modeling RAS Initiation Pathway for Cancer", the team's paper describes a method of predictively modelling the interactions between RAS proteins and the lipids that make up cell membranes. RAS signaling only becomes activated when the proteins are bound to lipid bilayers; therefore, understanding this interaction has wide-ranging implications for therapeutic intervention.

One of the paper's most innovative aspects is the development of a multiscale model that can provide high-resolution detail at a molecular level over long periods of time, an extremely challenging and resource-intense endeavour. The researchers also found that the model - called a Multiscale Machine-Learning Modeling Infrastructure, or MuMMI - is scalable for use on some of the most powerful computers in the world, including Lawrence Livermore National Laboratory's Sierra and Oak Ridge National Laboratory's Summit computers.

The NCI RAS Initiative, led by the Frederick National Laboratory, tested and validated predictions from the computer models to ensure their accuracy compared to experiment-derived biological interactions. This data was fed back into the simulations to improve the model. That iterative process helps to refine both high-powered computing and RAS research.

"The application of state-of-the-art molecular dynamic simulations to an intractable cancer biology problem is yielding unprecedented insights into cancer biology that may lead to new strategies for targeting KRAS-driven cancers", stated Dwight Nissley, Ph.D., who was a co-author on the study and is the director of the national lab's Cancer Research Technology Programme and head of the RAS Initiative.

The project is entering its fourth year and will next include the RAS effector protein RAF1 to better understand the activation of signaling that drives many cancers. The team will continue to use Department of Energy computers, including Summit at Oak Ridge National Laboratory, which is currently the world's most powerful supercomputer.
Source: Frederick National Laboratory for Cancer Research

Back to Table of contents

Primeur weekly 2020-01-13

Focus

Ambitious plans for e-IRG, EOSC and EuroHPC under Croatian EU Presidency - Interview with Ivan Maric, SRCE, Croatia ...

Quantum computing

Delta partners with IBM to explore quantum computing - an airline industry first ...

IBM working with over 100 organisations to advance practical quantum computing ...

New quantum loop provides long national testbed for quantum communication technology ...

The case of the elusive Majorana: The so-called 'angel particle' is still a mystery ...

World's first quantum-safe connected car secured by ISARA ...

Georgia Tech collaborates with IBM to develop software stacks for quantum computers ...

New York University partners with IBM to explore quantum computing for simulation of quantum systems and advancing quantum education ...

Focus on Europe

Barcelona Supercomputing Center coordinates the manufacture of the first open source chip developed in Spain ...

Atos empowers researchers at the University of Luxembourg with its BullSequana XH2000 supercomputer ...

Solemn inauguration of the HLRN-IV system ...

The European Commission is looking for IT specialists in HPC, Quantum, Infrastructure and Cloud ...

Dr. Alice-Agnes Gabriel wins 2020 PRACE Ada Lovelace Award for HPC ...

Middleware

Altair acquires newFASANT, further expanding high-frequency electromagnetics portfolio ...

Hardware

ECMWF signs contract with Atos for new supercomputer ...

World High Performance Computing (HPC) markets to 2025 - AI, IoT, and 5G will be major drivers for HPC growth as they facilitate the need to process vast amounts of data ...

IDC MarketScape names WekaIO as a major player in file-based storage ...

200G HDR InfiniBand to accelerate the new European Centre for Medium-Range Weather Forecasts (ECMWF) supercomputer ...

Applications

Frederick National Laboratory part of SC19 "Best Paper" team ...

Hyperion Research expands its analyst team ...

Supercomputer simulations showcase novel planet formation models ...

Satellite constellations harvest energy for near-total global coverage ...

Exploring the 'dark side' of a single-crystal complex oxide thin film ...

Sublimation, not melting: Graphene surprises researchers again ...

Persistence of gut microbial strains in twins, living apart after cohabitating for decades ...

Kun Sun and Sushil Jajodia receive funding for subcontract agreement ...

Decrappifying brain images with deep learning ...

Xylem expands regional headquarters in Singapore with new Technology Hub ...

The Cloud

Intel brings innovation to life with intelligent tech spanning the Cloud, network, edge and PC at CES 2020 ...

Los Alamos National Laboratory joins IBM Q Network to explore quantum computing algorithms and education outreach ...