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Primeur weekly 2017-01-30

Exascale supercomputing

Co-design centres to help make next-generation exascale computing a reality ...

Quantum computing

Supercool electrons ...

D-Wave announces D-Wave 2000Q quantum computer and first system order ...

Temporal Defense Systems purchases the first D-Wave 2000Q quantum computer ...

Fast track control accelerates switching of quantum bits ...

Focus on Europe

Bright Computing teams up with SGI to co-sponsor UK HPC & Big Data event ...

When life sciences become data sciences ...

PRACE Spring School 2017 - HPC for Life Sciences, registration is open ...

ITER and BSC tighten their collaboration to simulate the process of fusion power generation ...

Netherlands eScience Center to issue annual report ...

Middleware

BSC releases PyCOMPSs version 2.0 as a PIP installable package ...

Hardware

RSC gets the highest Elite status in the Intel Solutions for Lustre Reseller Programme ...

Finding a needle in the ocean ...

GIGABYTE selects Cavium QLogic 10/25GbE FastLinQ technology to power its next generation servers ...

Setting up light paths using the SURFnet Network Dashboard ...

Minerva will calculate gravitational waves faster than the Albert Einstein Institute's previous supercomputer ...

Applications

Big Brother will have some difficulty 'watching you' in future ...

Engineers eat away at Ms. Pac-Man score with artificial player ...

Mummy visualization impresses in computer journal ...

Berkeley launches RISELab, enabling computers to make intelligent real-time decisions ...

Model sheds light on inhibitory neurons' computational role ...

Using Big Data to understand immune system responses ...

Artificial intelligence uncovers new insight into biophysics of cancer ...

PPPL scientist uncovers physics behind plasma-etching process ...

Computer-aided drug design ...

IBM expands choices for PowerAI developers with TensorFlow ...

Hussein Aluie awarded hours on supercomputer at Argonne ...

CWI develops algorithms that shorten response time of ambulance ...

A rising peptide: Supercomputing helps scientists come closer to tailoring drug molecules ...

The Cloud

Oracle expands Startup Accelerator Programme to further promote global Cloud innovation ...

Technical computing hub UberCloud receives funding from Earlybird ...

Using Big Data to understand immune system responses

25 Jan 2017 Trondheim - Numerous researchers around the globe have begun to use the gene editing tool CRISPR to understand human biology. One of them is Associate Professor Richard Kandasamy at the Norwegian University of Science and Technology's (NTNU) Centre of Molecular Inflammation Research (CEMIR). Richard Kandasamy is working on understanding inflammatory reactions that occur in many diseases.

Using large amounts of data, his research reveals what happens minute-by-minute when the immune system responds to a virus. The results of his team's research were recently published in the respected online journalSystems Biology and Applications.

When the flu or any other virus attacks the body, it has to react with lightning speed.

"It's not like defense cells are just sitting around waiting in some corner of the body to gobble up viruses - and boom, it's all taken care of", stated Richard Kandasamy.

As Richard Kandasamy explained, "What happens inside the defense cells is a very comprehensive step-by-step reaction. Signals are sent to the nucleus to initiate a production of new proteins that will take part in the inflammatory reaction and that the cell will use to destroy the virus. This all takes some time. But even a tiny chemical modification of proteins in the cell also enables the cell to start reacting super quickly".

He and his team can map these reactions in extreme detail from the moment a virus infects a cell. By frequently repeating the mapping process in the hours after infection, they can create a detailed map of the cell's reactions.

Most scientists who are working on CRISPR research either proceed by analysing one gene at a time, or upwards of 20,000 genes at a time. Richard Kandasamy uses both approaches.

He also uses large computing systems to analyse this complex dataset. This approach of combining modern technologies and mapping reactions minute-by-minute is one of the unique approaches his research group uses to understand reactions in the cell.

Richard Kandasamy came to NTNU through the Onsager Fellowship programme, which is designed to recruit some of the most talented international young researchers to the university. Just before Christmas, Richard Kandasamy was awarded a generous grant for independent research from the Research Council of Norway's FRIPRO programme for promising young researchers.

Richard K. Kandasamy, Gregory I. Vladimer, Berend Snijder, André C. Müller, Manuele Rebsamen, Johannes W. Bigenzahn, Anna Moskovskich, Monika Sabler, Adrijana Stefanovic, Stefania Scorzoni, Manuela Brückner, Thomas Penz, Ciara Cleary, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett & Giulio Superti-Furga are the authors of the study titled " A time-resolved molecular map of the macrophage response to VSV infection ". It has been published innpj Systems Biology and Applications2, Article number: 16027 (2016).
Source: Norwegian University of Science andTechnology

Back to Table of contents

Primeur weekly 2017-01-30

Exascale supercomputing

Co-design centres to help make next-generation exascale computing a reality ...

Quantum computing

Supercool electrons ...

D-Wave announces D-Wave 2000Q quantum computer and first system order ...

Temporal Defense Systems purchases the first D-Wave 2000Q quantum computer ...

Fast track control accelerates switching of quantum bits ...

Focus on Europe

Bright Computing teams up with SGI to co-sponsor UK HPC & Big Data event ...

When life sciences become data sciences ...

PRACE Spring School 2017 - HPC for Life Sciences, registration is open ...

ITER and BSC tighten their collaboration to simulate the process of fusion power generation ...

Netherlands eScience Center to issue annual report ...

Middleware

BSC releases PyCOMPSs version 2.0 as a PIP installable package ...

Hardware

RSC gets the highest Elite status in the Intel Solutions for Lustre Reseller Programme ...

Finding a needle in the ocean ...

GIGABYTE selects Cavium QLogic 10/25GbE FastLinQ technology to power its next generation servers ...

Setting up light paths using the SURFnet Network Dashboard ...

Minerva will calculate gravitational waves faster than the Albert Einstein Institute's previous supercomputer ...

Applications

Big Brother will have some difficulty 'watching you' in future ...

Engineers eat away at Ms. Pac-Man score with artificial player ...

Mummy visualization impresses in computer journal ...

Berkeley launches RISELab, enabling computers to make intelligent real-time decisions ...

Model sheds light on inhibitory neurons' computational role ...

Using Big Data to understand immune system responses ...

Artificial intelligence uncovers new insight into biophysics of cancer ...

PPPL scientist uncovers physics behind plasma-etching process ...

Computer-aided drug design ...

IBM expands choices for PowerAI developers with TensorFlow ...

Hussein Aluie awarded hours on supercomputer at Argonne ...

CWI develops algorithms that shorten response time of ambulance ...

A rising peptide: Supercomputing helps scientists come closer to tailoring drug molecules ...

The Cloud

Oracle expands Startup Accelerator Programme to further promote global Cloud innovation ...

Technical computing hub UberCloud receives funding from Earlybird ...