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Primeur weekly 2012-12-10

The Cloud

Bull awarded for best Private Cloud project ...

Bull launches a new private Cloud data protection service ...

Bull extends its Le cloud by Bull offering, to help organisations reap the full benefit of the Cloud ...

Drag-and-Drop DNA: Novel technique aiding development of new cancer drugs ...

Galaxy on Cloud ...

IBM expands the power of social business with new Cloud and mobile advances ...

Oracle unveils Cloud and consolidation capabilities for Oracle SPARC SuperCluster ...

Desktop Grids

Call for Proposals for Open PhD Competition in Extreme Citizen Science ...

Crucial step in AIDS virus maturation simulated for first time ...

EuroFlash

SMB Engys buys hosted server cluster ...

HP harnesses the power of Big Data with new information optimization solutions ...

HP extends Converged Cloud Portfolio for hybrid delivery environments ...

HP redefines storage simplicity with single architecture for enterprises of all sizes ...

Sogeti consolidates client delivery centre infrastructure seeking business growth with IBM PureSystems ...

University of Manchester is celebrating supercomputing 50 years on ...

projectiondesign F32 projectors visualize the future for Petrobras Research Centres ...

Bismuth provides perfect dance partners for quantum computing qubits ...

USFlash

BP to build U.S. facility to house largest commercial research supercomputer in the world ...

Eurocom ships world's first 8-Core Intel Xeon E5-2690 based 12lbs supercomputer laptop ...

HP acknowledges global mission-critical computing innovators ...

Nextra Teleservices calls for IBM PureSystems over HP to deliver new high-speed broadband services in India ...

University of Kentucky takes academic supercomputing to next level ...

NCAR Officials to address supercomputer allocation use in 2013 ...

Interactive One connects with Oracle Database Appliance to meet high-traffic demands ...

Raritan announces first industry standard 802.11 Wi-Fi solution for intelligent power and environment ...

Grant creates science demilitarized zone at San Diego State University ...

Drag-and-Drop DNA: Novel technique aiding development of new cancer drugs

4 Dec 2012 Arlington - Using a simple "drag-and-drop" computer interface and DNA self-assembly techniques, researchers have developed a new approach for drug development that could drastically reduce the time required to create and test medications.

In work supported by a National Science Foundation (NSF) Small Business Innovation Research grant, researchers from Parabon NanoLabs of Reston, Virginia, recently developed and began evaluating a drug for combating the lethal brain cancer glioblastoma multiforme.

Now, with the support of an NSF Technology Enhancement for Commercial Partnerships (TECP) grant, Parabon has partnered with Janssen Research & Development LLC, part of the Janssen Pharmaceutical Companies of Johnson & Johnson, to use the technology to create and test the efficacy of a new prostate cancer drug.

"We can now 'print', molecule by molecule, exactly the compound that we want", stated Steven Armentrout, the principal investigator on the NSF grants and co-developer of Parabon's technology. "What differentiates our nanotechnology from others is our ability to rapidly, and precisely, specify the placement of every atom in a compound that we design."

The new technology is called the Parabon Essemblix Drug Development Platform, and it combines their computer-aided design (CAD) software called inSçquio with nanoscale fabrication technology.

Scientists work within inSçquio to design molecular pieces with specific, functional components. The software then optimizes the design using the Parabon Computation Grid, a Cloud supercomputing platform that uses proprietary algorithms to search for sets of DNA sequences that can self-assemble those components.

"When designing a therapeutic compound, we combine knowledge of the cell receptors we are targeting or biological pathways we are trying to affect with an understanding of the linking chemistry that defines what is possible to assemble", stated Hong Zhong, senior research scientist at Parabon and a collaborator on the grants. "It's a deliberate and methodical engineering process, which is quite different from most other drug development approaches in use today."

With the resulting sequences, the scientists chemically synthesize trillions of identical copies of the designed molecules. The process, from conception to production, can be performed in weeks, or even days - much faster than traditional drug discovery techniques that rely on trial and error for screening potentially useful compounds.

In vivo experiments, funded by the NSF SBIR award, validated the approach, and Parabon filed a provisional patent for its methods and compounds on May 4, 2011. The final application was published in 2012.

The process is characteristic of rational drug design, an effort to craft pharmaceuticals based on knowledge of how certain molecular pieces will work together in a biological system. For example, some molecules are good at finding cancer cells, while others are good at latching on to cancer cells, while still others are capable of killing cells. Working together as part of a larger molecule, these pieces could prove effective as a cancer treatment.

While there are other methods to create multi-component compounds, they generally take more time, and, most important, the majority of them lack the precise control over size, charge and the relative placement of components enabled by the new technology. The recent TECP grant provided a supplement to Parabon to support further research that will help the novel technologies meet market demands.

TECP grants are a mechanism available to NSF Phase II SBIR/STTR grantees, helping improve their commercial success by enabling them to build partnerships with larger companies and investors. Those partners generally require new products to meet set specifications and standards, and TECP supplemental awards provide funding for the research required to meet those parameters. As with Parabon and Janssen, the companies that partner with TECP grantees provide input that helps to further guide technological development.

"Partnerships are recognized as a critical success factor for small businesses commercializing technology", stated Ruth Shuman, the NSF programme director who oversees the NSF TECP effort. "However, potential partners frequently demand technical specifications and require proof-of-concept data as a prerequisite for partnership, requirements that are beyond the scope of small businesses' initial objectives. This supplemental funding enables small businesses to conduct additional research to meet the requirements of a corporate partner, potentially leading to commercial products and services, and a successful partnership."

The Parabon and Janssen researchers intend for their new prostate cancer drug to overcome several existing cancer-treatment obstacles. The drug design combines a toxin with a chemical that makes cancer cells susceptible to that toxin. Additionally, the drug incorporates components that improve delivery to cancer cells while avoiding healthy tissue, and chemical markers that allow researchers to monitor the drug's arrival at tumours. For the new compound, total design time plus synthesis time will be a matter of weeks.

"Currently, most drugs are developed using a screening technique where you try a lot of candidate compounds against targets to 'see what sticks'", stated Steven Armentrout. "Instead, we're designing very specific drugs based on their molecular structure, with target molecules that bind to receptors on specific types of cancer cells. In plug-and-play fashion, we can swap in or swap out any of the functional components, as needed, for a range of treatment approaches."

Concurrently, Parabon is developing other applications for the technology, including synthetic vaccines for biodefense and gene therapies that can target disease, based on information from an individual's genome. The technology also has applications outside of medicine, and Parabon's co-founders Chris Dwyer and Michael Norton are building upon the initial NSF-supported work to develop processes to create nanoscale logic gates, devices critical for computing, and molecular nanosensors.
Source: National Science Foundation

Back to Table of contents

Primeur weekly 2012-12-10

The Cloud

Bull awarded for best Private Cloud project ...

Bull launches a new private Cloud data protection service ...

Bull extends its Le cloud by Bull offering, to help organisations reap the full benefit of the Cloud ...

Drag-and-Drop DNA: Novel technique aiding development of new cancer drugs ...

Galaxy on Cloud ...

IBM expands the power of social business with new Cloud and mobile advances ...

Oracle unveils Cloud and consolidation capabilities for Oracle SPARC SuperCluster ...

Desktop Grids

Call for Proposals for Open PhD Competition in Extreme Citizen Science ...

Crucial step in AIDS virus maturation simulated for first time ...

EuroFlash

SMB Engys buys hosted server cluster ...

HP harnesses the power of Big Data with new information optimization solutions ...

HP extends Converged Cloud Portfolio for hybrid delivery environments ...

HP redefines storage simplicity with single architecture for enterprises of all sizes ...

Sogeti consolidates client delivery centre infrastructure seeking business growth with IBM PureSystems ...

University of Manchester is celebrating supercomputing 50 years on ...

projectiondesign F32 projectors visualize the future for Petrobras Research Centres ...

Bismuth provides perfect dance partners for quantum computing qubits ...

USFlash

BP to build U.S. facility to house largest commercial research supercomputer in the world ...

Eurocom ships world's first 8-Core Intel Xeon E5-2690 based 12lbs supercomputer laptop ...

HP acknowledges global mission-critical computing innovators ...

Nextra Teleservices calls for IBM PureSystems over HP to deliver new high-speed broadband services in India ...

University of Kentucky takes academic supercomputing to next level ...

NCAR Officials to address supercomputer allocation use in 2013 ...

Interactive One connects with Oracle Database Appliance to meet high-traffic demands ...

Raritan announces first industry standard 802.11 Wi-Fi solution for intelligent power and environment ...

Grant creates science demilitarized zone at San Diego State University ...